To Study The Effects of Omega 3 Fatty Acids In Patients With Meibomian Gland Dysfunction : A Randomised , Prospective Controlled Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Aim: To evaluate the role of Omega 3- fatty acids in patients with Meibomian gland dysfunction. Methods: A Prospective, interventional , placebo controlled, randomized study was done at Department of Ophthalmology, Rajindra Hospital , Patiala. Fifty (50) patients with Meibomian gland dysfunction fulfilling the inclusion criteria excluding the exclusion criteria were randomized into two groups – Group A and Group B containing 25 patients each. Group A patients treatment included cleaning the lid margins with neutral baby shampoo and use of artificial tears without preservatives, plus oral supplementation with one capsule (500 mg) two times a day containing 325mg EPA and 175mg DHA for 3 months. Group B patients treatment included cleaning the lid margins with neutral baby shampoo and use of artificial tears without preservatives, plus a placebo oral agent. for 3 months. Patients were followed in OPD at day 0 , 1 month , 2 month and 3 month. At every visit , slit lamp examination (severity of lid margin inflammation , meibomian gland secretion) , OSDI ( ocular surface index) and routine tear function test : Schirmer I test , tear film break-up time (TBUT) and Rose Bengal staining were performed. Data was collected and evaluated using unpaired –t test statistical analysis. Results: After 3 months of evaluation, the mean OSDI, TBUT and Rose Bengal staining presented significant improvement from the baseline values in Group A (p value< 0.001, p value<0.001 and p <0.05 respectively) as compared to Group B. The Schirmer test results were also improved and statistically significant (p<0.05). Conclusion: Oral omega 3 fatty acids 1g per day is beneficial in the treatment of MGD .
Authors and Affiliations
Dr. Harvinder Nagpal, Dr. Nidhi Rani, Dr. Seema Yadav, Dr. Mandeep Kaur
Keywords
Related Articles
- EP ID EP244072
- DOI 10.9790/0853-1610072429
- Views 72
- Downloads 0
Clinical profile and Outcome of Cortical Venous Sinus Thrombosis at a tertiary care centre
Background: Cortical Venous Sinus Thrombosis (CVST) is known to be a cause of stroke especially in the young population. It has a multifactorial etiology with a varied presentation. Given the increasing burden of this di...
A Correlative Study Of Serum Bilirubin And Liver Enzymes With Serum Ferritin In Beta Thalassaemia Major
Background: Beta-thalassemia is one of the most common hereditary hematologic disorders characterized by severely impaired β-globulin synthesis. Liver is the earliest site of iron deposition in transfusion dependent β -t...
Prospective Study of Results of Different Filling Methods of Bone Defect in Giant Cell Tumours
Giant Cell Tumour (GCT) is the most common bone tumour which the orthopaedic surgeon deals with. It is slow growing locally malignant tumour but for some reasons its detection is quite late therefore; it is often diagnos...
The All-On-Four Treatment Concept: A Case Report
The severely atrophied maxilla restricts implant placement mainly in the posterior region when using conventional techniques. The “All-on-4” concept could be a good alternative consisting in placing four implants in the...
Prevalence of Hepatitis C virus among voluntary blood donors of a blood bank in a mixed urban-rural setting in West Bengal, India
Background: Over 12 Million Indians Are Afflicted With Chronic Hepatitis C Infection, Says WHO. Prevalence Of HCV In Healthy Blood Donors Represents Prevalence Of Carrier State In The Population. High Rate Of Anti-HCV An...