To Study The Effects of Omega 3 Fatty Acids In Patients With Meibomian Gland Dysfunction : A Randomised , Prospective Controlled Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Aim: To evaluate the role of Omega 3- fatty acids in patients with Meibomian gland dysfunction. Methods: A Prospective, interventional , placebo controlled, randomized study was done at Department of Ophthalmology, Rajindra Hospital , Patiala. Fifty (50) patients with Meibomian gland dysfunction fulfilling the inclusion criteria excluding the exclusion criteria were randomized into two groups – Group A and Group B containing 25 patients each. Group A patients treatment included cleaning the lid margins with neutral baby shampoo and use of artificial tears without preservatives, plus oral supplementation with one capsule (500 mg) two times a day containing 325mg EPA and 175mg DHA for 3 months. Group B patients treatment included cleaning the lid margins with neutral baby shampoo and use of artificial tears without preservatives, plus a placebo oral agent. for 3 months. Patients were followed in OPD at day 0 , 1 month , 2 month and 3 month. At every visit , slit lamp examination (severity of lid margin inflammation , meibomian gland secretion) , OSDI ( ocular surface index) and routine tear function test : Schirmer I test , tear film break-up time (TBUT) and Rose Bengal staining were performed. Data was collected and evaluated using unpaired –t test statistical analysis. Results: After 3 months of evaluation, the mean OSDI, TBUT and Rose Bengal staining presented significant improvement from the baseline values in Group A (p value< 0.001, p value<0.001 and p <0.05 respectively) as compared to Group B. The Schirmer test results were also improved and statistically significant (p<0.05). Conclusion: Oral omega 3 fatty acids 1g per day is beneficial in the treatment of MGD .
Authors and Affiliations
Dr. Harvinder Nagpal, Dr. Nidhi Rani, Dr. Seema Yadav, Dr. Mandeep Kaur
Keywords
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- EP ID EP244072
- DOI 10.9790/0853-1610072429
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