Alpha-Lipoic Acid Effectiveness in Early Stages of Carpal Tunnel Syndrome: Short Term Follow-up
Journal Title: Journal of Orthopaedic Science and Research - Year 2021, Vol 2, Issue 2
Abstract
Carpal Tunnel Syndrome (CTS) is still the most common nerve compression syndrome of the upper extremity. The aim of this paper is to analyze the effectiveness of Alpha-Lipoic Acid (ALA) in early stages of carpal tunnel syndrome. We conducted a double-blind prospective study. A total of 84 patients with instrumental diagnosis of carpal tunnel syndrome at an early stage, based on nerve conductions study, were evaluated. The primary endpoint was the search for improvement of parameters in electrophysiological studies, correlated with the administration of ALA. Secondary endpoints were static 2-points discrimination and the Boston Carpal Tunnel Syndrome Questionnaire (BCTSQ). The statistical analysis has not shown any type of correlation between the evolution of electromyographic measurements and the administration of ALA (p-value> 1.2) On the other side, the statistical analysis showed an improvement regarding the 2-point discrimination and the BCTSQ (p-value <0.05). Alphalipoic acid did not improve nerve conduction velocity, but a statistically significant reduction of symptoms referred by the Boston Carpal Tunnel score, and an improvement of the two-point discrimination test was obtained.
Authors and Affiliations
Pegoli Loris, Lombardo Michele DM*, Mangiavini Laura, Peretti Giuseppe M
Keywords
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- EP ID EP698818
- DOI http://dx.doi.org/10.46889/JOSR.2021.2203
- Views 84
- Downloads 0
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