Alteration of blood cytokine content at shigellosis in children with helicobacter infection

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Alteration of blood cytokine content at shigellosis in children with helicobacter infection

Journal Title: ScienceRise: Medical Science - Year 2017, Vol 0, Issue 6

Abstract

Aim. The substantial incidence of acute enteric infection rate among children, especially associated with such bacterial pathogen as Shigella, makes the search for new methods of management and improved therapeutic approaches a matter of high priority in current medical science. Moreover, prior infection with Helicobacter pylori is considered to be one of the factors which impacts the course of the shigellosis in children. As the course of shigellosis and its consequences depend on balanced action of pro-inflammatory and anti-inflammatory interleukins and at present it is of a great concern, study is focused on assessment of anti-inflammatory interleukins content in blood serum of children with shigellosis and infected with H. Pylori.Methods. The study enrolled 113 children aged from 3 months to 3 years who were divided into two groups: Group 1 (37–32.74 %) represented by patients infected with H. pylori and Group 2 (76–67.26 %) made up by patients without laboratory markers of Helicobacter infection. The levels of IL-1β, TNF-α and IL-4 of blood serum were assessed for all children by means of solid-phase enzyme immunoassay in the acute period and during early convalescence.Results. It has been established that at the peak of the disease the IL-1β and TNF-α levels in patients of both groups were well higher than the indices of healthy children. At the same time in the children of Group 2 the concentration was well higher than the corresponding indices of Group 1 patients. Insignificantly increased levels of IL-4 as well as higher IL-4 content levels in children without background infection in comparison with those infected with H. pylori were revealed. However, in both cases this difference was not relevant. The convalescence period was not characterized by relevant difference of IL-1β and TNF-α indices between the study groups as well as by comparison of these indices in Group 2 and the control group. In the meantime, a significant difference between IL-1β and TNF-α levels is observed between the patients of Group 1 and the control group in the acute period. IL-4 content in blood serum of the children with shigellosis without background infection in the period of convalescence turned out to be well higher in comparison with that in apparently healthy children as well as in the patients infected with H. pylori who had higher IL-4 content, however the difference was not relevant.Conclusions. Present infection with H. pylori has a significant impact on the indices of pro- and anti-inflammatory interleukins of blood serum of the children with shigellosis both in the acute period and at the stages of early convalescence. The data obtained make it possible to deepen the idea concerned with immune pathogenic mechanisms of development and course of shigellosis in children infected with H. pylori and afterwards can be applied for improvement of therapeutic methods

Authors and Affiliations

Nataliia Kurlan

Keywords

shigellosis Нelicobacter рylori cytokines interleukins IL-1β TNF-α IL-4

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EP ID EP646373
DOI 10.15587/2519-4798.2017.104687
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