Alteration of Sex Hormone and Semen Parameters in Adult Males with Subclinical Hypothyroidism
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 23, Issue 3
Abstract
Aim: To investigate the correlation between subclinical hypothyroidism (SCH) with serum testosterone levels and semen parameters (sperm count, total motility and morphology) in men seeking medical care for sexual dysfunction and infertility. Study Design: Cross-sectional study. Place and Duration of Study: Department of Endocrinology, Gauhati Medical College and Hospital, Guwahati, India. Study done from November 2015 to December 2016. Methodology: The patients in study were grouped into two groups: Group I – Men with subclinical hypothyroidism (n=35) and group II – Euthyroid males serving as controls (n=27). The medical history, clinical examination, semen analysis, total thyroxine (T4), total triiodothyronine (T3), thyroid-stimulating hormone (TSH), Luteinizing hormone (LH), Follicular stimulating hormone (FSH), Total testosterone (T) and prolactin (PRL) were obtained. Patients with diabetes mellitus, hypertension, chronic diseases, any testicular or pituitary diseases and prior chemo-radiotherapy were excluded from study. Results: The age of the patients ranged between 24 and 42 years with mean age 31.57 years. The cases had significantly lower levels of mean serum total testosterone and free T4 and higher serum prolactin levels compared to controls (P< .01). Linear regression analysis showed TSH levels independently associated with low testosterone levels. Also men with subclinical hypothyroidism had lower total sperm motility with preserved sperm count and morphology. Conclusion: We found that SCH is associated with reduction in testosterone levels and total sperm motility. Our study data conclude that SCH may be a contributing factor for hypoandrogenemia and sexual dysfunction in men.
Authors and Affiliations
Dipti Sarma, Uma Kaimal Saikia, Darvin Vamadevan Das
Keywords
Related Articles
- EP ID EP312468
- DOI 10.9734/JAMMR/2017/35043
- Views 58
- Downloads 0
Adrenaline Induced Elevated Blood Pressure in Wistar Rats is not Reversed by Oral Administration of Archachatina marginata Hemolymph
Background: The increasing incidence of high blood pressure, its complications and associated fatalities has led to an upsurge in the use of alternate forms of medicaments in its management. The oral ingestion of the hem...
Can Right Heart Parameters of Runners Participating in High Altitude Race be Influenced by Training Altitude or Have Any Impact on Their Performances?
Objectives: This work was aimed at investigating, by means of ultrasonography, the influence of training altitudes on haemodynamic parameters of the right heart and the impact of these parameters on the performances of r...
Assessment of Porcelain Fused to Metal Crown Preparations by General Practitioners in Saudi Arabia
Background: Principles for fabricating prosthetic restorations include sufficient axial preparation and adequate occlusal clearance of the prepared teeth. This study measured the convergence angles in the prepared teeth...
Transferring High Quality Care of the Elderly into the Clinical Workplace: Barriers and Facilitating Factors
Introduction: Medical students experience difficulty transferring what they have learned in the classroom into the clinical workplace. Learning environments based upon whole-task learning can help medical students to app...
Roles of CD5+, CD19+, CD41a+, CD55+ and CD59+ in Chronic Immune Thrombocytopenic Purpura (ITP)
Aims: The aim of this study was to investigate of the roles of CD5+ and CD19+ on lymphocytes, CD5+ on B lymphocytes, CD41a+ on platelets and CD55+ and CD59+ on erythrocytes in platelet destruction; and evaluate them acco...