ALTERED INTERACTIONS OF BIOACTIVE FACTORS IN PRE-ECLAMPSIA
Journal Title: International Journal of Medical and Clinical Research - Year 2013, Vol 4, Issue 1
Abstract
Pre-eclampsia is a pregnancy specific syndrome characterised with hypertension, proteinuria and in severe cases manifest as hepatic, renal or CNS symptoms. Extensive studies on the etiological factors behind said syndrome have been carried out for the last three decades, however concrete evidence based information on its aetiopathogenesis is yet to be presented. The manifestations of Pre-Eclampsia, generally seen after 20 weeks of gestation, have been reported due to amalgamation of two major pathological events namely placental hypo-perfusion and endothelial cell injury and leading to the advancement of the disease. The main objective of this study is to review the recent reports & hypothesis regarding aetiology and pathophysiology of Pre-eclampsia and present an overview on viability of reported hypothesis based on the cumulative opinion to provide evidenced based knowledge on the various factors that may contribute and cause the aforesaid syndrome. The review suggests that development of preeclampsia involves interaction of many physiological processes resulting from altered hemodynamics attributed to circulatory biomarkers which in turn produce profound influence on blood flow and arterial blood pressure regulation. We also hypothesize that complete profile of vasoactive biomarkers needs to be evaluated in order to explore their pathophysiological role in aetiopathogenesis of preeclampsia. This paper thus provides scope for further research to study the effects of interplay of uteroplacental factors in the pathophysiology of preeclampsia.
Authors and Affiliations
A. B. CHATTOPADHYAY, R. C. SHARMA, R. K. SHARMA, S. SHARMA, R. SHARMA
Keywords
Related Articles
- EP ID EP170008
- DOI 10.9735/0976-5530.4.1.248-251
- Views 124
- Downloads 0
STANDARDIZATION OF EVALUATION TOOL BY COMPARING SPOT, UNSTRUCTURED VIVA WITH OBJECTIVE STRUCTURED PRACTICAL EXAMINATION IN MICROANATOMY
Evaluation of students is a vital component of any educational process and it is necessary to assess their performance. It also gets a feedback of teaching process so as to improve the performance of teacher and student...
TUMOR INDUCTION STUDIES IN DROSOPHILA MELANOGASTER USING TRYPTOPHAN
Tumor cells have an altered amino acid metabolism. They express high levels of tryptophan and L-arginine metabolizing enzymes. This leads to depletion of tryptophan and L-arginine and locally blocks T cell proliferation....
SAFETY IN HANDLING OF CADAVERS
Aim: To know the presence/ absence of infectious agents like: Bacterial Causes: Tuberculosis, Gram positive & Gram negative organisms. Viral Causes: HEPATITIS B&C; HIV in cadavers. Materials & Methods: Samples were colle...
THYROID FUNCTION TESTS IN NIGERIAN HIV SERO- POSITIVE PATIENTS ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)
Background: Recent studies suggest that the prevalence of hypothyroidism among human immunodeficiency virus (HIV) people who were on treatment with highly active antiretroviral therapy (HAART) was higher than that in tre...
A STUDY OF THE ROLE OF BACTERIAL VAGINOSIS IN PRETERM LABOUR FROM TERTIARY CARE HOSPITAL IN INDIA
Introduction- Preterm labour is a challenging issue for the obstetricians even today. It is the largest contributor to the perinatal morbidity and mortality throughout the world. With the improvement of neonatal care, th...