ALTERED INTERACTIONS OF BIOACTIVE FACTORS IN PRE-ECLAMPSIA
Journal Title: International Journal of Medical and Clinical Research - Year 2013, Vol 4, Issue 1
Abstract
Pre-eclampsia is a pregnancy specific syndrome characterised with hypertension, proteinuria and in severe cases manifest as hepatic, renal or CNS symptoms. Extensive studies on the etiological factors behind said syndrome have been carried out for the last three decades, however concrete evidence based information on its aetiopathogenesis is yet to be presented. The manifestations of Pre-Eclampsia, generally seen after 20 weeks of gestation, have been reported due to amalgamation of two major pathological events namely placental hypo-perfusion and endothelial cell injury and leading to the advancement of the disease. The main objective of this study is to review the recent reports & hypothesis regarding aetiology and pathophysiology of Pre-eclampsia and present an overview on viability of reported hypothesis based on the cumulative opinion to provide evidenced based knowledge on the various factors that may contribute and cause the aforesaid syndrome. The review suggests that development of preeclampsia involves interaction of many physiological processes resulting from altered hemodynamics attributed to circulatory biomarkers which in turn produce profound influence on blood flow and arterial blood pressure regulation. We also hypothesize that complete profile of vasoactive biomarkers needs to be evaluated in order to explore their pathophysiological role in aetiopathogenesis of preeclampsia. This paper thus provides scope for further research to study the effects of interplay of uteroplacental factors in the pathophysiology of preeclampsia.
Authors and Affiliations
A. B. CHATTOPADHYAY, R. C. SHARMA, R. K. SHARMA, S. SHARMA, R. SHARMA
Keywords
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- EP ID EP170008
- DOI 10.9735/0976-5530.4.1.248-251
- Views 97
- Downloads 0
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