Alzheimer’s Disease: AdultOnset of Inborn Error of Methionine Metabolism
Journal Title: Journal of Parkinson’s Disease and Alzheimer’s Disease - Year 2018, Vol 5, Issue 1
Abstract
The cause and treatment of Alzheimer’s Disease remains obscure. It could arise from adult onset of an inborn error of metabolism of the essential amino acid methionine expressed through an alternate biochemical pathway for methionine metabolism. This latter pathway generates homocysteine directly from methionine, accounting for the latter’s elevated vascular concentration in Alzheimer’s patients and those predisposed to this disease. Through this alternate pathway, synthesis of S-adenosylmethionine, an important component in memory retention, is precluded and accounts for the symptoms observed in patients. Suggestions for methods to increase brain concentrations of S-adenosylmethionine are presented.
Authors and Affiliations
Albert H. Soloway
Keywords
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- EP ID EP496829
- DOI 10.13188/2376-922X.1000026
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