ALZHEIMER‘S DISEASE: MEDICAL STRATEGIES
Journal Title: Българско списание за обществено здраве (Bulgarian Journal of Public Health) - Year 2018, Vol 0, Issue 3
Abstract
Alzheimer‘s disease (AD) is a socially significant, progressive neurodegenerative disease characterized by worsening of cognitive functions, impairment of behavioral functions, reduction of daily activities, associated functional decline, and ultimately the death of a patient occurs. There are numerous hypotheses about the aetiology and pathogenesis of the disease. One of the important pathogenetic hypotheses for AD is cholinergic, which is connected with degeneration of cholinergic neurons in the basal nuclei, which is associated with cognitive deficits. Therapeutic strategies for AD treatment include: Primary (Stabilizing Basic Symptoms) Therapy and - Secondary (Symptomatic) Behavioral Therapy. These strategies are not yet successful. Clinical research continues to look for new, more effective classes of medication that can be used in AD. In addition to synthetic medicinal products, clinical studies have been conducted on plants that have a favorable cognitive deficit in these patients (lemon balm, sage, sweet root, rosemary, ginkgo biloba, turmeric, common nettle, etc.). Preventive strategies for AD include: fight against risk factors (RF) - unhealthy diet; promoting the physical and cognitive activity; control of cardiovascular risk factors such as diabetes, high cholesterol, hypertension and smoking, etc. Despite the results of studies conducted in this field, the main conclusion is that patient care has a crucial role to play in the life span of patients with AD. These concerns are tied to serious financial resources.
Authors and Affiliations
Iliana Yaneva, Valentin Balabanski, Evgeni Grigorov
Keywords
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