Amelioration Effect of Emblica officinalis Extract on Ovary in Endosulfan Induced Swiss Albino Mice
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 11, Issue 2
Abstract
Background: In the present time use of pesticides has become very common by the farmers for the better yield of crops. Endosulfan, a chlorinated cyclodiene insecticide, is widely and very liberally used in agricultural sector. But it has created deleterious effects on human health. Objective: In the present study amelioration effect of Emblica officinalis (E. officinalis) extract on ovary in Endosulfan induced Swiss albino mice was studied. Materials and Methods: Three groups were formed, each with six mice. The control group of mice received distilled water as drinking water. The second group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks by Gavage method. The third group was exposed to Endosulfan @ 3 mg/kg body weight daily for 6 weeks followed by 6 weeks exposed to E. officinalis (100 mg/kg body weight) extract. Animals were sacrificed after the schedule treatment. Results and Discussion: Light microscopic observations showed various histopathological deformities in sections of treated ovary and improper development of follicle such as detached ova and degeneration of follicular cells due to Endosulfan exposure were also found. The present studies also indicate that alterations were found to be significantly ameliorated in E. officinalis extract treated group. Conclusion: It may be concluded from this study that E. officinalis have a potent capacity to control Endosulfan induced toxicity.
Authors and Affiliations
Preety Sinha, Arti Kumari
Keywords
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- EP ID EP342440
- DOI 10.9734/BJPR/2016/17669
- Views 55
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