Evaluation of the Anti-Inflammatory Activity of the Methanolic Extract of the Fruits of Ficus palmata
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 12, Issue 4
Abstract
Aim: This study was aimed to evaluate the possible in vivo anti-inflammatory activity of the methanolic extract of fruits of Ficus palmata. Place and Duration of the Study: In vivo studies were carried out in the Animal House of the S.B.S Ballawala Dehradun, Uttarakhand, India, between December 2014 and March 2015). Study Design: Three different doses of methanolic extract were tested in this study regarding their anti-inflammatory activity. Methodology: In vivo studies of anti-inflammatory effects of feeding adult albino rats under investigation with three different doses (50, 100 and 150 mg/kg-1) of methanolic extract were carried out after 24 hours of inducing inflammation by injecting investigated animals with carrageen. Results: The results of anti inflammatory activity study showed that the fruit extracts at doses of 50, 100 and 150 mg/mL inhibited carrageenan induced paw edema in rats. The percent inhibition of writhing response by the extract was 28.57, 56.08 and 58.73 respectively, after 4 h of Carrageenan induction. Conclusion: In the present work a potent anti-inflammatory activity of methanolic extract of the fruits of Ficus palmata were demonstrated, validating the ethno pharmacological claims. These experimental findings would further establish the scientific basis of the traditional uses of the plant in the management of inflammatory conditions as well as control of pain.
Authors and Affiliations
Subhash Chandra, Sarla Saklani
Keywords
Related Articles
- EP ID EP342212
- DOI 10.9734/BJPR/2016/25727
- Views 68
- Downloads 0
Anti-angiogenic Potential of Mentha longifolia (Horse Mint): Chlorioallantoic Membrane Assay
Inhibition of angiogenesis is one of the mechanisms of action of anticancer drugs. The current study was designed to probe into anti-angiogenic effect of Mentha longifolia by employing Chorioallantoic membrane assay. Whi...
Ion-pair HPLC Method for the Quantification of Metformin in Human Plasma and Its Application to a Pharmacokinetic Study
Aims: To develop and validate a rapid, selective and sensitive ion-pairing HPLC-UV method for the determination of metformin in human plasma, using a conventional reverse phase column. Study Design: Experimental study. P...
In vivo and in vitro Toxicity Studies of Crude and Partially Purified Leaf Extracts of Jatropha curcas in Wistar Albino Rats
Aims: Jatropha curcas (J. curcas) is a plant that has numerous medicinal and industrial applications. Evaluation of in vitro and in vivo acute/sub chronic hepato-renal toxicity of crude methanol J. curcas leaf extract on...
Formulation and Evaluation of Oxcarbazepine Suspension: In vitro/In vivo Correlation
Background: Information on economic burden of hypertension is needed for relevant decisions and policies due to escalating cost of disease management. Aims: The study assessed economic burden of pharmacotherapy in hype...
Assessment of Antibiotic Self-medication Pattern among University Students in Eastern Democratic Republic of the Congo
Background: Self-medication with antibiotics has been reported among university students in many countries, but no study has been conducted on this issue in Democratic Republic of the Congo (DRC). Aim: This study aimed...