Evaluation of the Anti-Inflammatory Activity of the Methanolic Extract of the Fruits of Ficus palmata
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 12, Issue 4
Abstract
Aim: This study was aimed to evaluate the possible in vivo anti-inflammatory activity of the methanolic extract of fruits of Ficus palmata. Place and Duration of the Study: In vivo studies were carried out in the Animal House of the S.B.S Ballawala Dehradun, Uttarakhand, India, between December 2014 and March 2015). Study Design: Three different doses of methanolic extract were tested in this study regarding their anti-inflammatory activity. Methodology: In vivo studies of anti-inflammatory effects of feeding adult albino rats under investigation with three different doses (50, 100 and 150 mg/kg-1) of methanolic extract were carried out after 24 hours of inducing inflammation by injecting investigated animals with carrageen. Results: The results of anti inflammatory activity study showed that the fruit extracts at doses of 50, 100 and 150 mg/mL inhibited carrageenan induced paw edema in rats. The percent inhibition of writhing response by the extract was 28.57, 56.08 and 58.73 respectively, after 4 h of Carrageenan induction. Conclusion: In the present work a potent anti-inflammatory activity of methanolic extract of the fruits of Ficus palmata were demonstrated, validating the ethno pharmacological claims. These experimental findings would further establish the scientific basis of the traditional uses of the plant in the management of inflammatory conditions as well as control of pain.
Authors and Affiliations
Subhash Chandra, Sarla Saklani
Keywords
Related Articles
- EP ID EP342212
- DOI 10.9734/BJPR/2016/25727
- Views 78
- Downloads 0
Acute and Subchronic Toxicity Studies of Aqueous, Methanolic and n-Hexane Root Extracts of Curcuma longa L. on Albino Rats
Introduction: The rapid increase in the use and consumption of herbal remedies worldwide has been stimulated by several factors, including the notion that most herbal products are safe and effective. Aim: This work was...
Cytotoxic Effect of Lingzhi Extracts on Gefitinib-resitant Lung Cancer Cells
Aims: The present study was carried out to investigate the cytotoxicity of extracts from Ganoderma and Amauroderma lingzhi species collected in Tay Nguyen, Vietnam. Methods: Mushroom samples were extracted by methanol an...
Toxic Effects of Aqueous Extract of Plectranthus amboinicus (Lour) Spreng on Allium cepa
Aims: Plectranthus amboinicus (Lour) Spreng. belonging to the Lamiaceae family being extensively used in folk medicine for its anti-inflammatory effects, nonetheless, there is a lack of more substantial data on the toxic...
Synthesis of Silver Nanoparticles and Incorporation with Certain Antibiotic Using Gamma Irradiation
Aims: The study was explaining that silver nanoparticles (AgNPs) were synthesized biologically by Bacillus megaterium culture supernatant (as reducing and stabilizing agents) by the optimization of medium components for...
HPLC, Densitometric and Visible-Spectrophotometric Determination of Triclabendazole and Ivermectin
Two methods were developed for simultaneous determination of triclabendazole and ivermectin, in addition to a Vis-spectrophotometric method for the analysis of ivermectin only. The first one was HPLC method in which effi...