AMELIORATIVE EFFECT OF CAROB AQUEOUS EXTRACT ON WATER PIPE SMOKE INDUCED-TOXICITY IN ADULT MALE ALBINO RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 1
Abstract
Objective: The aim of the present study was to investigate the daily effect of pre and post treatment of carob aqueous extract (600 mg/kg b. wt.); on rats exposed to were exposed to water pipe smoke (10 mg/kg; 15 minutes) for 2, 4, 6 and 8 w.Methods: Rats were divided into 6 groups; 1st group was served as a control. Rats of the 2nd group were administered amiodarone (an antiarrhythmic medication used as a model for lung toxicity) at a dose level of 30 mg/kg. The rats of 3rd and 4th groups were exposed to water pipe smoke and treated with carob extract respectively. However, the two remaining groups (5th and 6th) were the pre-and post-treatment groups with carob extract respectively.Results: Amiodarone and water pipe smoke induced a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP); on the contrary, induced a significant decrease in serum total protein and albumin. In addition; serum creatinine and urea showed a significant increase; as well as; amiodarone and water pipe smoke increased the oxidative stress (malondialdehyde/glutathione; MDA/GSH) in lung tissue homogenate. While; carob extract gavage showed protective and curative effects in liver and kidney functions; in addition; it decreased MDA level and increased GSH level significantly.Conclusion: Finally, we can conclude that the carob aqueous extract treatment revealed ameliorative effects on rats were exposed to water pipe smoke.
Authors and Affiliations
Mona Abdel Rahman, Fatma Elzahraa H. Salem, Amira A. Bauomy, Mona Ahmed Khalifa
Keywords
Related Articles
- EP ID EP575801
- DOI 10.22159/ijpps.2017v9i1.15470
- Views 41
- Downloads 0
ANTIOXIDANT, DNA DAMAGE PROTECTIVE AND HEPATOPROTECTIVE ACTIVITIES OF AMORPHOPHALLUS CAMPANULATUS
Objective: Amorphophallus campanulatus (AC) is commonly known as Suran. It is used to cure piles, deranged digestion and liver diseases. The present study was carried out to evaluate AC plant as a new source of natural b...
PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT POTENTIAL OF EUPHORBIA HETEROPHYLLA L
Objectives: The present study is to evaluate the preliminary phytochemical screening and in vitro antioxidant potential of Euphorbia heterophylla L.Methods: In vitro free radical scavenging activity of the chosen plant w...
COMPARATIVE IN VITRO DISSOLUTION STUDY ON METFORMIN MARKET PRODUCTS USING DIFFERENT DISSOLUTION APPARATUSES
Objective: This study was proposed to evaluate and compare the in vitro dissolution profiles of six Metformin Hydrochloride (MH) market products. Methods: Different dissolution apparatuses (USP apparatus II, IV and beak...
SYNERGISTIC EFFECT OF TWO COMBINATIONS OF SENNA PLANT ON THE TEGUMENT OF A RAT TAPEWORM HYMENOLEPIS DIMINUTA
Objective: Traditional systems of medicine have been adopted in different health care systems worldwide. Amongst them, plant and plant parts have been the most potential based. Our present study was conducted on the trea...
EVALUATION OF THE ANTIOXIDANT POTENTIAL FOR DIFFERENT EXTRACTS OF AL-TAIF POMEGRANATE (PUNICA GRANATUM L) INDUCED BY ATRAZINE AND MALATHION PESTICIDES IN LIVER OF MALE ALBINO MICE
Objective: The objective of the present study was to evaluate the antioxidant potential of Al-Taif Pomegranate Peel extract (PPE) and juice (PJ) induced by atrazine (Atra) and malathion (Mal) toxicity in male mice by usi...