Ameliorative Potentials of Methanol and Ethyl Acetate Fractions of Peristophe Bicalyculata on Streptozotocine -Induced Diabetic Rats
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2021, Vol 5, Issue 2
Abstract
Objective: The study investigated the ameliorative potentials of the ethyl acetate and methanol fractions of P. bicalyculata leaf extract on experimental rat models. Materials and Methods: A total of 35 albino Wistar rats were used for the study. They were randomly divided into 7 groups of 5 rats each. Group 1, the standard control, received 250mg/kg body weight (b.wt) of the anti-diabetic drug, Metformin, group 2 and 3 received 200 and 400mg/kg b.wt respectively of the methanol fraction of P. bicalyculata, (group 4 and 5 received 200 and 400mg/kg b.wt of the ethyl acetate fraction of P. bicalyculata respectively while groups6 and 7 were the diabetic control (DC) and normal control (NC) groups, respectively. Results: There was a significant decrease (p<0.05) in the serum levels of total cholesterol, TG, LDL, VLDL, and increased level of HDL cholesterol in streptozotocin (STZ) induced diabetic treated groups. The study also showed that there was a significant reduction in the fasting blood glucose (FBG) levels of the entire STZ induced diabetic rats treated with ethyl acetate and methanol extract of P. bicalyculata at 200mg/kg and 400mg/kg b.wt respectively. Also, the glycated haemoglobin and estimated average glucose concentrations showed a significant decrease (p<0.05) in the low and high doses of P. bicalyculata extract-treated groups compared to the DC. There was no significant (p>0.05) differences in the sex hormones (testosterone, luteinizing hormone and follicle stimulating hormone levels of rats in the treatment groups when compared to the NC group. Conclusion: The results obtained in the present study provide the scientific rationale for the use of P. bicalyculata as an antidiabetic agent in the management of diabetes.
Authors and Affiliations
Enobong JE, Eteng Ofem E*, Iwara Arikpo I, Joel A, Uboh FE and Ebong P
Keywords
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- EP ID EP748564
- DOI 10.23880/oajpr-16000238
- Views 35
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