AMINOMETHANESULPHONIC ACIDS AND ITS N-DERIVATIVES ARE COMPONENTS OF N. GOODS BUFFERS
Journal Title: Вісник Одеського національного університету. Хімія - Year 2015, Vol 20, Issue 3
Abstract
On the basis of pH measuring the temperature dependence of the second ionization constant (pK2) are set for aminomethansulfonic acid (AMSA) and its N-derivatives. It was found that the area of effective buffering of AMSK and its N-benzyl derivative allows to maintain the pH of acid-compatible with life. The absolute values of the coefficients in the equation pK2 = -Ai+ Bi/T for the aminosulfonic acids correlated with their molar masses. A simultaneous change in values DpH /DT and Bicoefficient for the studied acids QSAR method are stayed. The values of the distribution coefficients in the octanol – water (Pow) and molar refraction are calculated. In the future the data obtained in this study will be used to predict the physical, chemical and toxicological properties of the compounds studied.
Authors and Affiliations
R. E. Khoma, L. T. Osadchiy, R. M. Dlubovskiy
Keywords
Related Articles
- EP ID EP408932
- DOI 10.18524/2304-0947.2015.3(55).54005
- Views 76
- Downloads 0
EFFECTS OF KUYALNIK ESTUARY DEGRADATION (NORTHWEST BLACK SEA REGION, UKRAINE )
Based on the generalization of multiyear (2000-2013) comprehensive hydrological and hydrochemical research of Kuyalnik estuary aquatic and terrestrial ecosystems we identified causes and consequences of the degradation o...
DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism...
LUMINESCENT DETERMINATION OF TOTAL BITTER SUBSTANCES CONTENT IN HOPS
The possibility of determination of total bitter substances content in hops by sensitized Tb(III) ions luminescence is studied. The ligands under study contain a dicarbonyl fragment and, obviously, similar to β-diketones...
SPECTROSCOPIC STUDY OF INTERACTION OF SODIUM DOLUTEGRAVIR WITH HUMAN SERUM ALBUMIN
Drug-protein binding has become an important research field in life sciences, chemistry and clinical medicine. Under physiological conditions, in vitro interaction between the antiviral drug 2 Sodium (4R, 12aS)-9-{[(2,4-...
THE THEORY OF DEVELOPMENT OF SUPPORTED METAL-COMPLEX CATALYSTS
Some results of the investigations for the purpose of development of supported metal-complex catalysts for phosphine and carbon monoxide oxidation as well as for ozone decomposition are summarized. The activity of such c...