AMINOMETHANESULPHONIC ACIDS AND ITS N-DERIVATIVES ARE COMPONENTS OF N. GOODS BUFFERS
Journal Title: Вісник Одеського національного університету. Хімія - Year 2015, Vol 20, Issue 3
Abstract
On the basis of pH measuring the temperature dependence of the second ionization constant (pK2) are set for aminomethansulfonic acid (AMSA) and its N-derivatives. It was found that the area of effective buffering of AMSK and its N-benzyl derivative allows to maintain the pH of acid-compatible with life. The absolute values of the coefficients in the equation pK2 = -Ai+ Bi/T for the aminosulfonic acids correlated with their molar masses. A simultaneous change in values DpH /DT and Bicoefficient for the studied acids QSAR method are stayed. The values of the distribution coefficients in the octanol – water (Pow) and molar refraction are calculated. In the future the data obtained in this study will be used to predict the physical, chemical and toxicological properties of the compounds studied.
Authors and Affiliations
R. E. Khoma, L. T. Osadchiy, R. M. Dlubovskiy
Keywords
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- EP ID EP408932
- DOI 10.18524/2304-0947.2015.3(55).54005
- Views 70
- Downloads 0
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