An Assessment of Ant fertility Efficacy of Ethanol Extract of Celastrus Paniculatus Seed in Male Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Crude ethanolic extract of Celastrus paniculans L. seeds was administered to adult male albino rats for the evaluation of its antifertility effect. Aqueous solution of the extract, when administered orally for 45 days to cover the major portion of spermatogenesis at a dose level of 250 mg/kg body weight by oral route caused significant inhibition of spermatogenesis. There was a significant decrease in essential as well as accessory reproductive organs weight (p<0.05). Decrease in cauda epididymal sperm count and motility was noted. Cytoplasmic droplets in the mid-piece of sperms were seen, which is a sign of arrival of immature spermatozoa in cauda epididymis region. Testicular histology revealed arrest of spermatogenesis at the secondary spermatocyte stage. Early stages of maturation (primary and secondary spermatocytes) showed nuclear pyknosis and vacuolization with the presence of round cells and necrotic material in the tubular lumina. Biochemical estimations of marker testicular enzymes, lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GT) showed an increase whereas sorbitol dehydrogenase (SDH) activity was significantly decreased (p<0.05). These results suggest that C. paniculatus, may induce male infertility in rats, therefore, should be evaluated further as a potential antifertility agent.
Authors and Affiliations
Madhulika Singh, G. N. Verma, Kartar Srivastava
Keywords
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- DOI 10.9790/3008-1304016772
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