An association of lymph node status and estrogen progesterone receptors in patients with carcinoma breast
Journal Title: Medpulse International Journal of Surgery - Year 2018, Vol 8, Issue 3
Abstract
Background: Breast carcinoma is the 2nd most common carcinoma in woman and accounts to 22% of all female cancer, which is more than twice the prevalence of cancer in women at any other site. Aims and objective: To study the association of lymph node status and estrogen progesterone receptors in patients with carcinoma breast. Methodology: This study was carried out on patients coming to the Department of Surgery in Yenepoya Medical College Hospital from October 2013 to October 2015. Around 50 patients with breast carcinoma not treated by chemotherapy, radiotherapy, and hormonal therapy were included. The clinical information like age of the patient, age of menarche, age of menopause, parity of the patient, tumour size, number of lymph nodes and BMI were collected. The statistical analysis was done by Fisher Exact test. Result: Maximum people were in the age group of 45-50years. The specimen from these women was sent for estrogen and progesterone receptor status analysis. The mean age of the patients in the study is 48 years. Majority of patients had positive lymph node numbers between 4-10 and they were mostly estrogen receptor negative. It was found that, as the number of lymph nodes increased the estrogen receptors were negative. The results were highly significant (p<0.001). Similar comparison was made between the number of positive lymph nodes and the progesterone receptor status. Majority of patients had positive lymph node numbers 4-10 and they were mostly progesterone receptor negative. This result was highly significant (p<0.001). Conclusion: This was a prospective study and based on the results obtained from this study it can be concluded that the estrogen and progesterone receptor status is associated with Lymph node involvement. It was found that the number of lymph nodes affected increased as the negativity of the receptor increased. Receptor positive tumour was associated with less number of lymph node.
Authors and Affiliations
Karthik R Aithal, Ryan Denis Fernandes
Keywords
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