An Efficient Approach for Thio-Ether Bond Formation in Carbetocin
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 4
Abstract
An efficient approach for the formation of unnatural thio-ether side chain of carbetocin by performing the reaction using DMF and liquid Ammonia to produce Crude Carbetocin. Crude carbetocin SH was synthesized by solid phase synthesis. The cyclisation of Carbetocin-SH was done by variation in addition of carbetocin-SH and liquid ammonia in the reaction mixture. Cyclisation of carbetocin-SH was done using different pattern of input Raw-material and the dissolution of Carbetocin-SH. The approach was to avoid the dimer formation hindering the purification of Carbetocin and low yield.
Formulaion and Evaluation of Mucoadhesive Buccal Tablets of Atenolol by Using Natural Polymers
The main aim of the present work was to formulate and evaluate mucoadhesive buccal tablets of Atenolol an anti-hypertensive drug using natural polymers. Buccal mucosa is the preferred site for both systemic and local dru...
Effect of delay of fixation on mitotic counts in histopathological sections of tumors
Mitotic count is the most commonly used method of assessing the proliferative activity of a tumor. Mitotic count should be done very meticulously because it is used to evaluate prognosis of various tumors and is one of t...
Approaches to Treat Palato Radicular Groove Based on its Anatomy: Series of 3 Cases
Palatoradicular groove is a developmental anomaly which is most often observed in maxillary lateral incisors. This case report describes the successful treatment palatoradicular grooves with varying depth and extent in t...
The Peak Expiratory Flow Rates of Petrol Station Attendants in Nnewi Using a Wright Peak Flow Meter
This is a study on peak expiratory flow rates (PEFR) of petrol station attendants using a Wright peak flow metre, conducted on 30 petrol station attendants within Nnewi town, Anambra State and 20 control (students of col...
Drug Information Services in Resource-Limited Settings: A Case of Drug Information Center in Gondar University Hospital, Northwest Ethiopia
Objective: The main objective of this study was to evaluate the drug information queries received by the drug information center of Gondar University Hospital in Northwest Ethiopia. Method: A retrospective review of drug...