Abstract

An efficient approach for the formation of unnatural thio-ether side chain of carbetocin by performing the reaction using DMF and liquid Ammonia to produce Crude Carbetocin. Crude carbetocin SH was synthesized by solid phase synthesis. The cyclisation of Carbetocin-SH was done by variation in addition of carbetocin-SH and liquid ammonia in the reaction mixture. Cyclisation of carbetocin-SH was done using different pattern of input Raw-material and the dissolution of Carbetocin-SH. The approach was to avoid the dimer formation hindering the purification of Carbetocin and low yield.

Authors and Affiliations