Abstract

Depression is one of the major mental disorders. It affects up to 25% of women and 12% of men and is a highly chronic disorder. Antidepressant drugs used in the treatment of major depressive disorders are believed to act on the central monoaminergic systems mainly 5-HT and nor-adrenergic synaptic neurotransmissions. Selective serotonin reuptake inhibitors and noradrenaline reuptake inhibitors are effective in treating most depressive episodes, but about one third of these patients show only partial or no response to the treatment. Therefore, research for new antidepressants with greater effectiveness is still desirable. The presence of phenols gives the leaves of urena lobata the potent antiseptic bactericidal properties and this supports the use of the leaves extract in rheumatism, gonorrhea treatment and in preventingthe formation of infections. The leaves have high saponin contents. Saponins have the tendency to fight microbes. They are well known for their homeostatic activities because of their characteristic soapy nature. Overall results of the present investigation demonstrated that Urena lobata leaf extract could be the better alternative for maintaining the anxiety, depression and inflammatory conditions. These Studies lead to the conclusion that the herbal extract of Urena lobata leaf extract could be used for the treatment of anxiety, depression and inflammatory, as they are found to be potent and safe.

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