A Review on ATP Binding Cassette (ABC) Transporters
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 2
Abstract
ATP binding cassette (ABC) transporters form a special famil of membrane proteins, characterized by homologous ATP-binding, and large, multispanningtransmembrane domains. Several members of this family are primary active transporters, which significantly modulate the absorption, metabolism, cellular effectivity and toxicity of pharmacological agents. ABC transporters can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are highly expressed in bronchial epithelium. This review provides a general overview of the human ABC transporters, their expression, localization and basic mechanism of action in a brief manner.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP313559
- DOI -
- Views 87
- Downloads 0
Formulaion and Evaluation of Mucoadhesive Buccal Tablets of Atenolol by Using Natural Polymers
The main aim of the present work was to formulate and evaluate mucoadhesive buccal tablets of Atenolol an anti-hypertensive drug using natural polymers. Buccal mucosa is the preferred site for both systemic and local dru...
Human Brucellosis Presenting as Pyrexia of Unknown Origin with Splenic Micro Abscesses in a South Indian HIV Infected Patient: A Case Report
A 33 year old HIV positive male patient rearing one domestic cattle presented with complaints of low back pain for 30 days, Fever with Chills and Rigors and non productive cough of 15 days duration. USG Abdomen showed Sp...
Antitumour Activity of Ecteinascidia venui Meenakshi, 2000 against Dalton’s Lymphoma Ascites
The aim of this study is to investigate the in vitro cytotoxicity and antitumor effect of the ethanol extract of colonial ascidian Ecteinascidia venui Meenakshi, 2000 in Swiss albino mice against Dalton’s Lymphoma Ascite...
Development and Validation of UV Spectrophotometric Method for Estimation of Metronidazole in Tablet Dosage Form
A simple, rapid and accurate spectrophotometric method has been developed for estimation of metronidazole. The method involved measurement of absorbance at wavelength 320 nm using water as the solvent. The method was val...
Morphological Study of Sulci and Gyri of Occipital Lobe of Cerebral Hemisphere of Human Brain
The occipital lobe of the cerebral hemisphere of human brain is a conical lobe which lies behind the parieto-occipital sulcus on its medial surface, and posterior to an imaginary line drawn on the superolateral surface o...