Antioxidant and Antiulcer Activity of Curculigo orchioides Rhizomes Extract on Experimental Animals
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2017, Vol 5, Issue 4
Abstract
Curculigo orchioides Gaertn (Hypoxidaceae) is used traditionally in Indian system of medicine as carminative, indigestion, vomiting, diarrhoea and aphrodisiac. Ulcer in either the stomach or duodenum is called as peptic ulcer, which is one of the common problem in human population. This study aimed to evaluate the antiulcer activity of Curculigo orchioides rhizome. Curculigo orchioides rhizome extract 50-200mg/kg administered orally, twice daily for 5 days for prevention from aspirin induced, ethanol, cold restraint stress and pylorus ligation induced ulcer. Estimation of antioxidant enzyme activity and various gastric secretion parameter like volume of gastric juice, acid output, pepsin and gastric pH value carried out in CRS and PL induced ulcer model respectively.COE showed dose dependent decrease in ulcer index in different ulcer model with decrease in SOD and LPO while increase in CAT level in PL induced ulcer model. COE also showed marginal decrease in volume, acid pepsin concentration and output. The result showed that COE possesses antiulcer property with significant antioxidant potential.
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