An efficient approach to the synthesis of some novel heterocycles related to indoline moiety using [BMIm]Cl catalysis
Journal Title: Asian Journal of Green Chemistry - Year 2017, Vol 1, Issue 2
Abstract
The combination of isatins, active methylene reagents and 4-phenylurazole/ phthalhydrazide in the presence of ionic liquid ([BMIm]Cl) as a solvent catalyst was found to be a suitable and efficient method for the synthesis of the biologically important spirooxindoles. The features of this procedure were characterized by one-pot procedure, reasonable reaction times, fairly high yields, and simple isolation procedures. The ionic liquid can be easily separated and reused for several times.
Authors and Affiliations
Leila Youseftabar-Miri, Hamide Hosseinjani-Pirdehi
Keywords
Related Articles
- EP ID EP252343
- DOI 10.22631/ajgc.2017.95721.1017
- Views 108
- Downloads 0
Chemoselective synthesis of 1,1-diacetates (acylals) using 1,1'‐butylenebispyridinium hydrogen sulfate as a new, halogen‐free and environmental-friendly catalyst under solvent-free conditions
In this study, an efficient and simple procedure is reported for the chemoselctive acetylation of various aldehydes (aromatic and aliphatic) with acetic anhydride by 1,1'‐butylenebispyridinium hydrogen sulfate (Bbpy)(HSO...
Tribromo melamine (TBM) as an efficient and inexpensive catalyst for the one-pot synthesis of benzimidazoles and benzoxazole derivatives
In this work, a simple and facile method for the preparation of tribromo melamine (TBM or melamine‐Br3) as an environmentally friendly homogeneous catalyst is described as it is used for the one-pot synthesis of benzimid...
Solvent-free synthesis for imidazole-1-yl-acetic acid hydrochloride: an intermediate for zoledronic acid
A convenient and environmentally-friendly protocol for the preparation of imidazol-1-yl-acetic acid hydrochloride is described via solvent-free N-alkylation of imidazole by tert-butyl chloroacetate, the obtained imidazo...
Sulfonylbis(1,4-phenylene)bissulfamic acid (SPSA): Introduction of an efficient and reusable catalyst for the synthesis of bis(indolyl)methanes
A simple, efficient and convenient route is described for the synthesis of bis-indolyl methanes by using recyclable catalyst sulfonylbis(1,4phenylene)bissulfamic acid (SPSA). In this procedure, we synthesize a bis-indoly...
Stability indicating assay method for simultaneous estimation of nebivolol and valsartan in pharmaceutical dosage form by RP-HPLC
A simple, rapid, precise, and accurate isocratic reversed-phase stability indicating HPLC method was developed and validated for simultaneous determination of the nebivolol and valsartan in the tablet dosage form. The ef...