An hydroxytyrosol-based pharmaceutical formulation for the prevention of cardiovascular disease: a randomized controlled crossover trial.
Journal Title: Biomedicine & Prevention - Year 2017, Vol 2017, Issue 1
Abstract
Background and aim: Inflammation and oxidative damage contribute significantly to the development of chronic non-communicable diseases (CNCD). Hydroxytyrosol (3,4 dihydroxyphenylethanol; 3,4-DHPEA or HT), abundant in extra virgin olive oil (EVOO), plays a significant role in cardiovascular diseases (CVDs). The aim was to determine the effect in healthy volunteers of two gastro-resistant capsules containing 7.5 mg/capsule/day of HT. Methods: This clinical study was a randomized double-blinded, controlled crossover trial to determine the acute effect of two gastro-resistant capsules containing 7.5mg of HT on healthy volunteers. Evaluation of nutritional, serum metabolites, oxidative stress biomarkers and gene expression of 9 genes related to oxidative stress, inflammation and CVDs was performed. Results: Oxidative stress biomarkers, like thiols groups and total antioxidant status, were significantly increased, while nitrite and nitrate, and lipid peroxidation values were drastically reduced. Significant up-regulation of superoxide dismutase-1 was observed. These results could be associated with the significant increase in plasma concentration of HT. Conclusions: European Food Safety Authority (EFSA) scientific opinion has acknowledged the possibility to make health claims, under the provisions of Regulation EC 1924/2006, for extra virgin olive oil (EVOO) or food supplements from EVOO that provide a HT content of at least 5 mg/die in a balanced diet. This study highlights the possibility to prevent oxidative stress damages in the post prandial time, with an intake of 15 mg/day of HT, able to modulate the anti-oxidant profile and the expression of SOD1, an oxidative-stress-related gene. Chronic studies on a larger population are necessary before definitive conclusions can be drawn.
Authors and Affiliations
Laura Di Renzo, Domenico Trombetta, Antonella Smeriglio, Stefano Cascapera, Carmela Colica
Keywords
Related Articles
- EP ID EP334905
- DOI 10.19252/00000005C
- Views 150
- Downloads 0
Genomic Personalized Medicine: a dream or a reality?
The inter- individual variability is an evident phenomenon: everyone shows different phenotypic features, as well as each person has a different susceptibility to various multifactorial diseases, or is more or less resis...
Technical Rescue Dynamic Response In High Visibility Events - Operational Concepts And CBRN Aspects
Over the last few years, several situations have emerged related to high visibil-ity events, which are of an extraordinary character and can get sensible targets. The day after 9/11, the entire society and safety and sec...
An hydroxytyrosol-based pharmaceutical formulation for the prevention of cardiovascular disease: a randomized controlled crossover trial.
Background and aim: Inflammation and oxidative damage contribute significantly to the development of chronic non-communicable diseases (CNCD). Hydroxytyrosol (3,4 dihydroxyphenylethanol; 3,4-DHPEA or HT), abundant in ext...
Nutritional counseling improves dietary diversity and feeding habits of Zambian malnourished children admitted in Rainbow nutritional programs
Background. Adequate nutrition is essential for child growth, health and development. In sub-Saharan African countries children’s feeding habits are often inappropriate, with monotonous diet, insufficient in food quality...
An informatics tool to analyse child growth indexes: first results of Mid-Upper Arm Circumference (MUAC) software
Nowadays, health problems related to malnutrition still threats several countries. Undernutrition problems are more spread in low-income countries and high level of this malnutrition usually led to infant and premature d...