Genomic Personalized Medicine: a dream or a reality?
Journal Title: Biomedicine & Prevention - Year 2016, Vol 2016, Issue 0
Abstract
The inter- individual variability is an evident phenomenon: everyone shows different phenotypic features, as well as each person has a different susceptibility to various multifactorial diseases, or is more or less resistant to infectious agents. Moreover, each individual responds very differently to the same drug, both in terms of efficacy and toxicity. While a part of this variability is due to "environmental" factors, an important contribution is due to genetic factors. The huge biotechnology development permitted in the last years an enormous increase of knowledge regarding the genetics field and its possible applications. This progress in the knowledge of the human genome sequence and of its inter-individual variability has consequently permitted a considerable impact of the genomics on the clinical practice and in particular in the field of prevention in its different aspects. In particular, in the last decade there was an important development of Pharmacogenomics: its aim is to study the genetic inter-individual variability involved in in the response to a drug, identify "responders" and "non-responders", identify people who have a high risk to experience toxicity and help the development of new “personalized” or “tailored” drugs. Here we discuss how the idea of a "Genomic Medicine " or " Preventive Personalized Medicine" can be considered no more a dream but a real perspective.
Authors and Affiliations
Paola Borgiani
Keywords
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- EP ID EP334250
- DOI 10.19252/00000001D
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