An improved, scalable and robust process for the synthesis of cilastatin sodium: A renal dehydropeptidase inhibitor
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 9
Abstract
An improved process developed for the synthesis of API, Cilastatin Sodium with more than 99.5% purity and all impurities well below the regulatory limits. The process was specially modified to control the epimeric impurities; solvent purification methods have been developed to achieve desired quality of API without any use of either column chromatography or ion-exchange chromatography.
Authors and Affiliations
Sachin Sonavane
Keywords
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