An in vitro evaluation of a guar gum matrix formulation targeting colon, using ibuprofen as a model drug
Journal Title: International Journal of Pharmaceutical Science and Technology - Year 2012, Vol 7, Issue 1
Abstract
The concentration of a drug in the blood fluctuates over successive administrations of conventional single unit dosage forms. The main reason for this is because conventional dosage forms are designed to release the complete dose of the drug immediately after administration ( i.e. burst release effect). These fluctuating drug blood levels can be addressed by means of formulating dosage forms with predetermined drug release profiles. Specific targeting of drugs to the colon has several therapeutic advantages. Drugs which are destroyed by the stomach acid and/or metabolized by pancreatic enzymes are slightly affected in the colon, and sustained colonic release of drugs can be useful in the treatment of nocturnal asthma, angina and arthritis, ulcerative colitis, colorectal cancer and Crohn's disease. The matrix tablet of ibuprofen were subjected to in vitro drug release studies in simulated colonic fluids (4% w/v of rat caecal contents) obtained after oral treatment of rats for 7 days of 2% w/v guar gum (1 ml) after completing the dissolution study in 0.1 M HCl. (2 h) and pH 7.4 phosphate bufferStatistically significant differences were observed in drug release profiles from the different polymer combinations. The release kinetics have been found to be governed by the type and content of polymer in the matrix system. Higher polymeric content of guar gum (70%) decreased the release rate of drug because of the increased tortuosity and decreased porosity
Authors and Affiliations
KHIDIR AGAB MOHAMMED HASSAN
Keywords
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