An in vivo study on anti inflammatory activity of Siddha drug Gandhaga Choornam
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 5
Abstract
To evaluate the acute toxicity and anti inflammatory activities of Ganthaga chooranam (sulphur) in siddha drug. In context, the acute toxicity of Ganthaga chooranam was evaluated by oral administration to make rates as single doses of 5, 50,300, and 2000 mg/kg body weight. General behaviour and toxicity symptoms were observed for 14 days. The anti inflammatory activity was evaluated in carrageenan induced inflammatory paw oedema and activity in male rat. No signs of acute toxicity were observed, including that the LD50 is greater than 2000mg/kg. Ganthaga chooranam (45 and 180mg/kg) significantly reduced oedema formation and at higher dose, the reduction was similar to dexamethasone. The present study shows that Ganthaga chooranam has anti inflammatory properties in rats without causing acute toxicity. These properties observed may be due to the presence of nano substance of sulphur.
Authors and Affiliations
Dr. Manigandan G*1 , Dr. Sharmila A2 Dr. Vimala C3
Keywords
Related Articles
- EP ID EP563115
- DOI 10.22192/ijcrms.2018.04.05.004
- Views 112
- Downloads 0
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