An intervention study of right unilateral modified electroconvulsive therapy for major depressive disorder
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 6
Abstract
ObjectiveTo explore the effect and safety of right unilateral modified electroconvulsive therapy (RUL-MECT) for major depressive disorder patients (MDD).MethodsA randomized controlled trial was conducted on 70 patients with MDD who were randomly divided into a study group and a control group. The study group underwent age-based RUL-MECT, while the control group underwent bitemporal MECT. The participants were evaluated using the 17-item Hamilton depression scale (HAMD-17), MATRICS consensus cognitive battery (MCCB) and orientation recovery tests (ORT). Any adverse reactions that occurred during each intervention process were recorded.ResultsBefore treatment, there were no significant differences in the HAMD-17 (32.89±5.68 vs.33.54±4.78) between the two groups (P>0.05). The HAMD-17 score of the intervention group was 6.83±4.68, while the control group was 7.20±4.60 after 8 interventions, repeated measures analysis of variance showed the time effect (P<0.001) was significant. The intergroup effect and interaction effect was not significant (P>0.05). In terms of MCCB scores, there were significant main effect (P<0.001) in connectivity tests, symbol coding, language memory, spatial breadth, number sequence, maze test, visual memory, emotional management and the duration of continuous operation. The intergroup effects of language memory, number sequence, visual memory, speech fluency, and continuous operation were significant (P<0.05). The interaction effect of language memory and continuous operation were significant (P<0.05). After the intervention, the recovery of orientation time was significantly shorter in the study group than that in the control group [(508.57 ± 104.48) s vs. (631.66 ± 212.27) s] (P<0.05). The incidence of adverse reactions between two groups (28.6% vs. 40.0%) has no significance (P>0.05).ConclusionsCompared with bitemporal MECT, RUL-MECT has comparable efficacy in treating depressant and better performance in improving cognitive function and recovery of orientation.
Authors and Affiliations
TAN Pei,FU Yixiao,LUO Qinghua,DU Lian,QIU Tian,QIU Haitang,
Keywords
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