Research progress on brain structure and function in patients with major depressive disorder after modified electroconvulsive therapy
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 8
Abstract
Modified electroconvulsive therapy (MECT) has a good therapeutic effect on major depressive disorder (MDD), but its mechanism of action is still unclear. In recent years, accumulated studies have confirmed the effects of MECT on brain structure and function using neuroimaging techniques and large datasets obtained through global collaborations and the conclusions are becoming increasingly consistent. For example, there is an increase in gray matter volume in specific brain regions such as the hippocampus and amygdala, an increase in white matter microstructural integrity and normalization of brain functional connections associated with MDD, such as the hippocampus-amygdala-subgenual anterior cingulate cortex-prefrontal cortex network, hippocampus-thalamus-temporal cortex-parietal cortex network, etc. However, the relationship between these changes and the mechanism of MECT action still needs further investigation. This review provides an overview of the research progress on the structural and functional changes of the brain by MECT to provide methodological support and theoretical basis for its better application in clinical diagnosis and treatment.
Authors and Affiliations
Yiyi YANG, Yawen HONG, Yongguang HE, Jijun WANG, Tianhong ZHANG
Keywords
Related Articles
- EP ID EP750533
- DOI 10.3969/j.issn.1002-0152.2024.08.009
- Views 63
- Downloads 0
Functional near-infrared spectroscopy on anhedonia in schizophrenia and major depressive disorder
[Objective] To explore the differences in brain activation related to anhedonia in patients with schizophrenia (SCZ) and major depressive disorder (MDD) during a verbal fluency task (VFT) based on functional near-infrare...
Research status of non-drug treatment of vestibular migraine
Due to the limitations of drug treatment of vestibular migraine VM,the exploration of non-drug treatment is particularly important. In recent years,the research on non-drug treatment of VM mainly focuses on four aspects:...
The electrophysiological characteristics of primary hamster cortical neurons with Mg2+-free external
[Objective] To investigate the electrophysiological characteristics of hamster primary cortical neurons by using the whole-cell patch-clamp recordings in a Mg2+-free cell model of epilepsy. [Methods] The cerebral cortex...
Incidence and predictors of early radial artery occlusion associated transradial approach
ObjectiveThis study was to explore factors related to early radial artery occlusion (RAO) associated transradial approach(TRA).MethodsPatients who underwent the TRA from July 2021 to Jan 2024 were included in our study....
Research progress on physical pain and social pain in non-suicidal self-injury and their influencing factors
Non-suicidal self-injury is a prevalent pathological behavior in clinical settings, significantly impacting both physical and mental health. Non-suicidal self-injury is closely associated with the abnormal perception of...