An Investigation of the Relationship between PPP1R3 Gene Polymorphism and Type 2 Diabetes
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 5
Abstract
Background and Objectives: PPP1R3 is one of the genes confirmed to be associated with type 2 diabetes. This gene is located on the long arm of chromosome 7 and encodes protein phosphatase 1 (PP1), which has serine/threonine phosphatase activity. There is a polymorphic region in the 3'UTR region of this gene, which creates ARE1 and ARE2 alleles. The aim of this study was to determine the relationship between PPP1R3 gene polymorphism and type 2 diabetes. Methods: In this case-control study, 100 patients with type 2 diabetes and 100 healthy individuals, were randomly selected from the study population. PPP1R3 gene polymorphism was analyzed using PCR-RFLP method. Comparison of variables between healthy and patient groups, was performed by t-test, allele frequency by counting, and calculation of their ratio by chi-square test, and the population was confirmed to be in Hardy-Weinberg equilibrium. Distribution of genotypes and alleles was compared between healthy and patient groups. Results: In this study, there was no significant difference between the frequency of genotypes and frequency of alleles in subjects with type 2 diabetes and healthy control subjects. Conclusion: The findings of this study indicated that polymorphisms in the 3'UTR region of PPP1R3 gene is not associated with type 2 diabetes.
Authors and Affiliations
Soyar Soyar, Golnar Golnar
Keywords
Related Articles
- EP ID EP464730
- DOI -
- Views 54
- Downloads 0
The Effect of Circular Resistance Training on Serum Level of IL-17 and Immunoglobulins M, A, G in Obese Handicapped Men
Background and Objectives: One of the important functions of the immune system is producing soluble or cellular components that protect the body against any threats. The aim of the present study was to investigate the ef...
Comparison of Declared Performance of Primary School Girl Students in the Context of Individual Health Behavior in Health Promoting Schools (HPS) and Ordinary Schools in 3rd District of Karaj (Iran)
Background and Objectives: Health promoting school project that is a health promotion system, is being conducted in some schools in Iran. The purpose of the present research was to compare the performance declared by pri...
The Effect of 8 Weeks of Moderate-Intensity Endurance Training on Serum Levels of Liver Enzymes and Insulin Resistance Index in Women with Type 2 Diabetes
Background and Objectives: Type 2 diabetes is the most common type of diabetes and liver damage is one of its most important complications. In the present study, the effect of endurance training, was investigated on plas...
The Tendency to Leave Nursing Profession and Some Related Factors at the Therapeutic and Educational Centers of Qom City, (Iran)
Background and Objectives: The tendency to leave nursing profession can exacerbate the shortage of nursing workforce and ultimately will have negative effects on the quality of health care provision. The aim of this stud...
بررسی اپیدمیولوژیک سل خارج ریوی در استان قم، طی سالهای 1394-1387
زمینه و هدف: سل یک بیماری عفونی مهم است که معمولاً به دو شکل ریوی و خارج ریوی طبقه‌بندی می‌شود. امروزه، سل خارج ریوی تقریباً یک‌سوم موارد مبتلایان به سل را تشکیل می‌دهد. با توجه به روند صعودی بروز سل خارج ریوی در کشور، ا...