An observative study of comparison of efficacy and tolerability between amolodopine and atenolol in the maintence therapy of hypertension in a tertiary care hospital
Journal Title: International Journal of Pharmacology and Clinical Research (IJPCR) - Year 2017, Vol 1, Issue 2
Abstract
Background Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age. The beta receptor antagonists provide effective therapy for all grades of hypertension. Compared with other classes of antihypertensive agents, there is a greater frequency of achieving blood pressure control with Ca channel blockers as monotherapy. Because of paucity of published reports in the Indian literature regarding the pattern of use, efficacy, safety, tolerability of comparison of therapy of amolodopine and atenolol, the present study was taken up. Objectives To study the comparison of efficacy, safety and tolerability of amolodopine and atenolol in achieving blood pressure control. Materials and methods 100 properly selected subjects with hypertension were included for the present study. The medication were used empirically as monotherapy, OD or BID in a continuation manner. Blood pressure was measured at the baseline and daily afterwards for one month. The data collected was analyzed statistically using descriptive statistics. Tolerability and patient compliance for the prescribed medications were also assessed during the follow up visits. Results Blood pressure is maintained at the baseline level in both the study subjects. A few subjects with atenolol shows more blood pressure variability compare to amolodopine. Minor side effects were noted in both the subjects with nearly same frequency. The patient compliance for the prescribed medications was excellent. Interpretation and conclusion International Journal of Pharmacology and Hypertension can be effectively treated by monotherapy of amolodopine or atenolol. Each one can be used depending upon the particular patient.
Authors and Affiliations
Dr. Syed Wasif
Keywords
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