An Open Label Prospective Study to Evaluate the Efficacy of Entecavir in HBeAg Positive Treatment Naive Chronic Hepatitis –B Patients in A Tertiary Care Centre in Eastern India

Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6

Abstract

Background: Entecavir is a nucleoside analogue drug that has selective anti-hepatitis B virus (HBV) activity. It is indicated for the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication, persistent elevations in serum aminotransferase and histologically active disease. We conducted a study to evaluate the efficacy of entecavir (ETV) in hepatitis Beantigen (HBeAg) positive- chronic hepatitis B (CHB) treatment naive Indian patients in real life scenario. Method: This is a single center open label prospective observational study to evaluate the efficacy of Entecavir in chronic hepatitis B patients. A total of 140 patients were enrolled in the study from January 2015 to December 2016. Parameters were evaluated at baseline and at 12, 24 and 40 weeks of the treatment, Efficacy of entecavir was assessed by evaluating hepatitis B virus DNA (HBV DNA), serum alanine aminotransferase (ALT) and sero-conversion. Result: The mean HBV DNA at baseline was 5.99 log [on a base-10 scale] IU/mL which decreased to 2.12 log IU/mL at the end of 40 weeks. Thus there was a mean change of 3.87 log IU/ml which was statistically significant (P<0.0001). Out of 140 HBeAg positive subjects, 50 (35.71 %) had become negative at the end of 40 weeks. Only 10.71% of the patients had normal ALT (<40IU/l) values in the beginning which increased to 100% at the end of 40 weeks. Conclusion: Entecavir significantly improves virological, biochemical and serological markers in HBeAg positive treatment naïve chronic hepatitis B patients.

Authors and Affiliations

Jayanta Kumar Panda

Keywords

Related Articles

A ‘cut off’ value of ‘AP measurement to Transverse measurement Ratio (A/T Ratio)’ for a provisional diagnosis of malignancy in sonologically confirmed solitary nodules of the thyroid

Introduction: The low accuracy of ultrasound features for diagnosing malignancyin the thyroid justifies the widespread use of FNAC on sonologically selected nodules. The sonographic feature, ‘height more than width’or in...

Role of C Reactive Protein and WBC Count in the Diagnosis of Acute Appendicitis and Its Predictive Value in Assessing the Severity of the Disease

Introduction: Acute appendicitis is still one of the commonest surgical emergencies. The diagnosis is primarily clinical based on the typical presentation of right lower quadrant pain, nausea and vomiting with tenderness...

Effects of Maternal Hemoglobin on Fetal Birth Weight

Studies on the association between maternal hemoglobin (Hb) concentration and adverse pregnancy outcome have been inconsistent. Many studies have shown the impact of Hb concentration on pregnancy outcomes in adult women;...

Changing trends in the Antibiotic susceptibility pattern of Acinetobacter species isolated from clinical specimens over a period of five years from a tertiary care hospital

`Introduction: Acinetobacter spp has emerged as an important nosocomial pathogen worldwide. Antimicrobial resistance pattern of Acinetobacter vary according to species, country of isolation, region & period of time. But...

A prospective study to evaluate the incidence of Palmoplantar Psoriasis in North Region of India

Background: Psoriasis is a common and chronic T cell mediated skin disorder with varied clinicomorphological types. Most of the published studies have reported chronic plaque type psoriasis to be the commonest type. Aim...

Download PDF file
  • EP ID EP285648
  • DOI -
  • Views 79
  • Downloads 0

How To Cite

Jayanta Kumar Panda (2017). An Open Label Prospective Study to Evaluate the Efficacy of Entecavir in HBeAg Positive Treatment Naive Chronic Hepatitis –B Patients in A Tertiary Care Centre in Eastern India. Journal of Medical Science And clinical Research, 5(6), 22810-22815. https://europub.co.uk/articles/-A-285648