AN OVERVIEW OF NSAIDS USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND PREVENTION GASTROINTESTINAL DAMAGE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 8
Abstract
Nonsteroidal anti-inflammatory agents/analgesics (NSAIDs) are a class of drugs that provide analgesic, antipyretic (fever-reducing) and in higher doses anti-inflammatory effects. The term "nonsteroidal" distinguishes these drugs from steroids, which among a broad range of other effects, have a similar eicosanoid-depressing, antiinflammatory action. As analgesics, NSAIDs are unusual in that they are non narcotic. Nonsteroidal antiinflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, antiinflammatory, and antipyretic actions may be beneficial, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen. All of the drugs are available over the counter in most countries. NSAIDs are usually indicated for the treatment of acute or chronic conditions where pain and inflammation are present. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold annually in the United States. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.
Authors and Affiliations
Satya Prakash Singh*| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Satish Kumar Sharma| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Lalit Singh| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Sandhya Goyal| Department of Pharmaceutics, ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, Punjab, India., Jineetkumar B. Gawad| Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy & Research, Palghar (East), Thane, Maharashtra, India.
Keywords
Related Articles
- EP ID EP1445
- DOI -
- Views 486
- Downloads 28
Method development and validation using HPLC technique – A review
Analytic method development and validation are key elements of any pharmaceutical development program. HPLC analysis method is developed to identify, quantity or purifying compounds of interest. This article mainly focus...
INVESTIGATION OF IN VITRO ANTHELMINTIC ACTIVITY OF FICUS ELASTICA LEAVES
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. The increasing of anthelmintic drug resistance and the high cost of anthelmintic drugs led to the development...
Cooking oil rancidification during deep frying causes health hazards
Many factors can affect the tendency of oil to become rancid. The first is too much exposure to air. Since oxidative rancidity is the most likely kind of rancidity to affect food oils, always want to keep those oils in b...
Paclitaxel- protein bound particles for Injectable suspension a choice of drug for metastatic breast carcinoma
Paclitaxel Protein Bound Particles is a type of Medical Treatment Called Chemotherapy. The Purpose of Chemotherapy to Kill Cancer Cell or Prevent the Growth. When cancer develops from Breast tissue signs of breast Cancer...
Pharmacopoeia reflects on permissible pharmaceutical impurities in parts per million limits
PAT (Process Analytical Technology) produces enormous amount of inorganic impurities during unit operation. Inorganic impurities are mostly ionic matters which are water soluble cations & anions. Cations are iron (Fe2+/F...