AN OVERVIEW OF NSAIDS USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND PREVENTION GASTROINTESTINAL DAMAGE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 8
Abstract
Nonsteroidal anti-inflammatory agents/analgesics (NSAIDs) are a class of drugs that provide analgesic, antipyretic (fever-reducing) and in higher doses anti-inflammatory effects. The term "nonsteroidal" distinguishes these drugs from steroids, which among a broad range of other effects, have a similar eicosanoid-depressing, antiinflammatory action. As analgesics, NSAIDs are unusual in that they are non narcotic. Nonsteroidal antiinflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, antiinflammatory, and antipyretic actions may be beneficial, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen. All of the drugs are available over the counter in most countries. NSAIDs are usually indicated for the treatment of acute or chronic conditions where pain and inflammation are present. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold annually in the United States. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.
Authors and Affiliations
Satya Prakash Singh*| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Satish Kumar Sharma| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Lalit Singh| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Sandhya Goyal| Department of Pharmaceutics, ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, Punjab, India., Jineetkumar B. Gawad| Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy & Research, Palghar (East), Thane, Maharashtra, India.
Keywords
Related Articles
- EP ID EP1445
- DOI -
- Views 511
- Downloads 28
Screening of solvent extracts of catharanthus roseus l. for isolation of anti-inflammatory compound
Catharanthus roseus (L.) which is an important medicinal plant of the family Apocynaceae is used to treat many of the fatal diseases. C. roseus also possess good antioxidant potential. Catharanthus roseus, is a potent me...
Pharmacovigilance in psychiatry: time to take notice
The term ‘Pharmacovigilance’ is used to describe the activities that are related to monitoring adverse drug reactions (ADRs). The World Health Organization (WHO) defines it as “the science and activities relat...
Knowledge, attitude and practice of medicated contraception among females of reproductive age group
Lack of knowledge of contraception has lead to increased maternal mortality, morbidity due to unsafe abortion. Hence our study was aimed to determine knowledge, attitude and practice of contraception and impact of socio...
Phyto-chemical Evaluation of extracts of Cajanus cajan Linn.
Phytochemicals are chemical compounds that occur naturally in plants (phyto means plant in Greek).Some are responsible for color and the organoleptic properties. Some phytochemicals with physiological properties are elem...
EVALUATION OF COSMETIC PROPERTIES OF DIFFERENT BRANDS OF SHAMPOOS FROM MULTINATIONAL BRANDS IN OMAN
Shampoo is a hair care product used for the removal of oils, dirt, skin particles, dandruff, environmental pollutants and other contaminant particles that gradually build up in hair. Shampoos are products which remove su...