AN OVERVIEW OF NSAIDS USED IN ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND PREVENTION GASTROINTESTINAL DAMAGE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 8
Abstract
Nonsteroidal anti-inflammatory agents/analgesics (NSAIDs) are a class of drugs that provide analgesic, antipyretic (fever-reducing) and in higher doses anti-inflammatory effects. The term "nonsteroidal" distinguishes these drugs from steroids, which among a broad range of other effects, have a similar eicosanoid-depressing, antiinflammatory action. As analgesics, NSAIDs are unusual in that they are non narcotic. Nonsteroidal antiinflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, antiinflammatory, and antipyretic actions may be beneficial, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen. All of the drugs are available over the counter in most countries. NSAIDs are usually indicated for the treatment of acute or chronic conditions where pain and inflammation are present. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold annually in the United States. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.
Authors and Affiliations
Satya Prakash Singh*| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Satish Kumar Sharma| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Lalit Singh| Sunder Deep Pharmacy College, Ghaziabad, UP, India- 201001, Sandhya Goyal| Department of Pharmaceutics, ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, Punjab, India., Jineetkumar B. Gawad| Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy & Research, Palghar (East), Thane, Maharashtra, India.
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