FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF TIZANIDINE HYDROCHLORIDE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 1
Abstract
The aim of this study was to formulate and evaluate the sustained release matrix tablet of Tizanidine hydrochloride. Tizanidine hydrochloride tablets were prepared by wet granulation technique using different polymers like propyl methyl cellulose (HPMC) K 100, ethyl cellulose and gaur gum alone or in combinations. Prepared tablets were evaluated for weight variation, hardness, friability, content uniformity and dissolution studies. % Cumulative drug release from all the prepared formulations were found to be in following order: F4 > F1 > F5 > F2 > F5 > F3. The result indicated that formulation (F4) containing mixture of two polymers HPMC K 100 and ethyl cellulose showed the release profile for 14 hours and high drug content.
Authors and Affiliations
Harish Rathi*| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Patel Pinkesh| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Umesh Kumar| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Patel Shreya| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
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