FORMULATION AND OPTIMIZATION OF ONDANSETRON HYDROCHLORIDE ORODISPERSIBLE TABLETS
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 3
Abstract
The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Orodispersible tablets of Ondansetron hydrochloride were prepared to achieve quick onset of action and for maximum bioavailability. The objective of the present research was to compare the effect of different superdisintegrants on the mouth dissolving property of Ondansetron hydrochloride tablets. Orodispersible tablets of Ondansetron hydrochloride were prepared using sodium carboxy methyl cellulose, alginic acid, crospovidone, croscarmellose sodium and sodium starch glycollate as superdisintegrants by direct compression technique. Prepared orodispersible tablets were evaluated for weight variation, hardness, friability, content uniformity, wetting time, in vitro dispersion time, in vitro disintegration time and dissolution studies. Disintegration time from all the prepared formulation was found to be in following order: F3<F5<F1<F4<F2. Disintegration time was found to be rapid in F3 formulation. The in vitro dissolution time was found to be 99.77 ± 0.32 in 10 minutes for the formulation F3. Sodium starch glycollate (SSG) showed faster disintegration of tablets among all other superdisintegrants.
Authors and Affiliations
Asija Rajesh*| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Patel Shreya| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Asija Sangeeta| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur
Keywords
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