IKBKE GENE-A NEWLY POTENTIAL THERAPEUTIC TARGET FOR TREATING NON-SMALL CELL LUNG CANCER
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 3
Abstract
The IKBKE gene is part of a family of enzyme complexes involved in increasing cellular inflammation. IKBKE over expression has been associated with breast and prostate cancers. However, it had not been linked to environmental carcinogen, such as tobacco smoke, until now. Tobacco smoke is the strongest documented initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Authors and Affiliations
Gaurav Singh*| Department of Pharmacology, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007, Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074, Anil Kumar Gupta| Research Scholar, Bhagwant University, Institute of Pharmacy & Research Center, Ajmer, Rajasthan, India-305004, Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Sojitra Ishita| Department of Pharmaceutics, Parul Institute of Pharmacy, Vadodra, Gujarat, India- 391760, Bhupender Nimbiwal| Department of Quality Assurance, Seth G. L. Bihani S. D. College of Technical Education, IPSDR, Sri Ganganagar, Rajasthan, India-335001, Garima Bharti| Department of Physiology, Bhojia Dental College and Hospital, Nalagarh Road, Budh, Baddi, Himachal Pradesh, India-173205
Keywords
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