Topical ointment: an updated review
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 1
Abstract
The main advantage of topical delivery system is to bypass the first pass metabolism, avoidance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastric emptying time and presence of enzyme. The skin is an organ, which consists of the epidermis, the dermis and the hypodermis. Its main functions are to protect and enclose the body, to regulate body temperature, eliminate waste materials, aid in absorption and in the perception of stimuli such as touch, pain, temperature and pressure. The skin has a slightly acidic pH that ranges between 4 and 6.This forms an effective antiseptic layer and retards the growth of bacteria and fungi on the skin surface.
Authors and Affiliations
Rajesh Asija| Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Sangeeta Asija| Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Deepak Sharma| Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Prem Chand Dhaker| Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Nitin Nama| Department of pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020
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