An overview on applications of retinal organoid derivatives
Journal Title: Eye Science (Yanke Xuebao) - Year 2022, Vol 37, Issue 4
Abstract
Retinal degenerative diseases, characterized by severe retinal cell loss at the end stage, are of various kinds and haunt vast amounts of patients. Retinal organoid (RO) with complete retinal cell subtypes and classic retinal stratification structures can be obtained in large quantities through stem cells in vitro 3D differentiation and culture method. Therefore, RO can serve as one of the best ways for retinal degenerative disease modeling to facilitate the decipherment of underlying pathogenic mechanisms. At present, RO derivatives have been widely used in animal experiments and clinical studies of retinal cell replacement therapy with varying results possibly affected by cell quantity, time window, or tools in terms of transplantation. With the booming progress of RO-related research, the diagnosis and treatment on molecular and individual level for retinal degenerative diseases will be further improved.
Authors and Affiliations
Haohao CHEN, Zibing JIN
Keywords
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- EP ID EP763650
- DOI 10.3978/j.issn.1000-4432.2022.02.03
- Views 15
- Downloads 0
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