AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2013, Vol 6, Issue 4

Abstract

Liver is a vital organ, contributing in most of the metabolic and physiological processes of our body. It plays principal role in detoxification of various drugs and xenobiotics. Though liver possess tremendous regenerative capacity, but metabolism of various chemicals severely damage the hepatic system. Drug induced hepatotoxicity (DIHT) is a major concern in this respect. The drugs we consume to treat various diseases, very often, their metabolic intermediates cause liver toxicity. The lion’s share of the idiosyncratic drug reactions ultimately results either in liver transplantation or even death. DIHT is a major medical concern at present and several drugs have been withdrawn from the market due to their hepatotoxic phenotype. Therefore, considering the phenomenon of DIHT, we have documented various aspects of DIHT, also discussing about the mode of toxicity of the drugs.

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  • EP ID EP470347
  • DOI -
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How To Cite

(2013). AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY. Asian Journal of Pharamceutical and Clinical Research, 6(4), 1-4. https://europub.co.uk/articles/-A-470347