AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2013, Vol 6, Issue 4

Abstract

Liver is a vital organ, contributing in most of the metabolic and physiological processes of our body. It plays principal role in detoxification of various drugs and xenobiotics. Though liver possess tremendous regenerative capacity, but metabolism of various chemicals severely damage the hepatic system. Drug induced hepatotoxicity (DIHT) is a major concern in this respect. The drugs we consume to treat various diseases, very often, their metabolic intermediates cause liver toxicity. The lion’s share of the idiosyncratic drug reactions ultimately results either in liver transplantation or even death. DIHT is a major medical concern at present and several drugs have been withdrawn from the market due to their hepatotoxic phenotype. Therefore, considering the phenomenon of DIHT, we have documented various aspects of DIHT, also discussing about the mode of toxicity of the drugs.

Authors and Affiliations

Keywords

Related Articles

EFFECT OF OPUNTIA ELATIOR ON CHOLESTEROL LEVEL ALTERATIONS INDUCED BY GAMMA RADIATION IN SWISS ALBINO MICE

Objectives: Radiotherapy is deleterious to patient health by making the patient more susceptible to other diseases and often causes death by weakening the immune system and also affects cholesterol level. Based on these...

GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF VIBURNUM OPULUS (L) EXTRACT AND ITS TOXICITY STUDIES IN RATS

Objectives: This study was aimed at establishing the antimicrobial and phytochemical profiles of Viburnum opulus (L) as well as the safety potential of the extract in albino Wistar rats.Methods: Ethanol, n-hexane, ethyl...

SYNTHESIS AND ANTIPLASMODIAL ACTIVITY OF SOME NOVEL CHALCONE DERIVATIVES

Increased drug resistance in malaria toward many of the existing antimalarials make the condition worse. Hence, indicates the necessity of thenovel molecules to overcome the problem. A series of chalcone derivatives (3a-...

ACTIVE PHENOLIC CONSTITUENTS AND BRINE SHRIMP LETHALITY ASSAY OF HYDROALCOHOLIC EXTRACT OF Plectranthus amboinicus

Objective: Plectranthus amboinicus, (PA) leaves contain pharmaceutically important phyto constituents that attribute to greater medicinal values. The purpose of the present study was to investigate the active principles...

A SODIUM HYALURONATE OPHTHALMIC SOLUTION FOR REDUCING DRY EYE AND ENHANCING CORNEAL WOUND HEALING AFTER PHOTOREFRACTIVE KERATECTOMY (PRK)

 Objective: The objective of this work was to evaluate the efficacy and safety of 0.3% sodium hyaluronate (SH) versus hydroxypropyl-methylcellulose(HPMC)/dextran in reducing dry eye symptoms, recovering tear film functi...

Download PDF file
  • EP ID EP470347
  • DOI -
  • Views 174
  • Downloads 0

How To Cite

(2013). AN OVERVIEW ON DRUG-INDUCED HEPATOTOXICITY. Asian Journal of Pharamceutical and Clinical Research, 6(4), 1-4. https://europub.co.uk/articles/-A-470347