Analgesic activity of aqueous extract of Vernonia hymenolepis (A. Rich) a traditional medicine plant used in Kenya for toothache
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 6
Abstract
The main aim of the study was to ascertain the analgesic properties of Vernonia hymenolepis leaves to validate its use for the treatment of toothache. The plant is widely used as a traditional herb by communities in Trans Nzoia County, Kenya for treatment of various infections including toothache. However its efficacy has not been established. Leaves of the plant were collected from Trans Nzoia County, Kenya and identified at University of Nairobi Herbarium. An aqueous extraction of leaves was prepared. Formalin test was carried out using 30 male albino wister mice to determine antinociceptive effect and the painful response at 0 – 10 min (Early) and 15 – 60 min (late phase). Acetylsalicylate at dose of 100 mg/Kg was used as a positive control. The dose significantly (p<0.05) reduced the time spent in pain behavior in both phases hence indicating that the plant posses antinociceptive activity. It’s concluded that Vernonia hymenolepis possesses analgesic property.
Authors and Affiliations
R. O. Onzago ,S. G. Kiama, J. M. Mbaria, D. W Gakuya, C. G. Githiji, Z. M. Rukenya
Keywords
Related Articles
- EP ID EP49535
- DOI -
- Views 206
- Downloads 0
Impact of Solanum surettense on membrane bound Na+/K+ ATPase and in vivo anti oxidants activity on isoproterenol induced myocardial injury in rats
The present study was designed to evaluate the cardio protective potential of ethanolic extract of Solanum surettense a warm-climate annual herb, on isoproterenol-induced Myocardial Infarction (MI) in rats. Five groups...
Baillonella toxisperma improves sexual performance and protects against stress-induced reproductive dysfunction in male Wistar rats
Baillonella toxisperma Pierre (Sapotaceae) is a medicinal plant widely used in Central Africa against several diseases including erectile dysfunction and male infertility. However, no study dealing with these male repr...
Cytotoxicity assessment of the stem bark of Tieghemella heckelii Pierre ex. A Chev. (Sapotaceae) towards Vero and RD human cancer Cell Lines
The present study aimed at investigating the cytotoxicity of the stem bark of Tieghemella heckelii Pierre ex. A Chev (Sapotaceae). For this purpose, plant extracts were put into contact separately with the different Ver...
Quantifying phytophenols in Andrographis paniculata and Withania somnifera leaf extracts
Andrographis paniculata (Nilavembu) and Withania somnifera (Ashwagandha) are some of the commonly available herbs, used for treating a wide range of ailments in man and animals. Both the plants possesses a wide spectru...
Cultivation, distribution, taxonomy, chemical composition and medical importance of Crocus sativus
Crocus sativus L. is one of the most important plant belongs to family Iridaceae. It is having various medicinal potential, and is widely being used in food industries. In Jammu and Kashmir State, its cultivation is res...