Analgesic activity of aqueous extract of Vernonia hymenolepis (A. Rich) a traditional medicine plant used in Kenya for toothache
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 6
Abstract
The main aim of the study was to ascertain the analgesic properties of Vernonia hymenolepis leaves to validate its use for the treatment of toothache. The plant is widely used as a traditional herb by communities in Trans Nzoia County, Kenya for treatment of various infections including toothache. However its efficacy has not been established. Leaves of the plant were collected from Trans Nzoia County, Kenya and identified at University of Nairobi Herbarium. An aqueous extraction of leaves was prepared. Formalin test was carried out using 30 male albino wister mice to determine antinociceptive effect and the painful response at 0 – 10 min (Early) and 15 – 60 min (late phase). Acetylsalicylate at dose of 100 mg/Kg was used as a positive control. The dose significantly (p<0.05) reduced the time spent in pain behavior in both phases hence indicating that the plant posses antinociceptive activity. It’s concluded that Vernonia hymenolepis possesses analgesic property.
Authors and Affiliations
R. O. Onzago ,S. G. Kiama, J. M. Mbaria, D. W Gakuya, C. G. Githiji, Z. M. Rukenya
Keywords
Related Articles
- EP ID EP49535
- DOI -
- Views 225
- Downloads 0
Biological activities and phytochemical analysis of extracts Afrostyrax lepidophyllus Mildbr. seeds
Oxidative stress, one of the causes of certain diseases, prompts the search for new antioxidant molecules to reduce or limit the damage caused by it. In this study, the antioxidant, anti-inflammatory and anti-xanthine...
Evaluation of Zanthoxylum armatum its toxic metal contents and proximate analysis
The objective of this study was to determine the elemental contents and proximate analysis of leaves, bark and fruit of Zanthoxylum armatum. The worth of natural medicines cannot be ignored anywhere the globe but the a...
Antipyretic effect of a polyherbal ayurvedic formulation: A randomized controlled clinical study
The ancient ayurvedic text Aṣṭāṅgahṛdaya of Vāgbhaṭa (7th Century A.D.) prescribes a specific formulation of four plants having antipyretic properties with minimal side-effects. This polyherbal ayurvedic formulation co...
Phytochemical screening and antimicrobial activity studies of underground bulbs of Ledeboria hyderabadensis
Plants are good source for the bioactive compounds and are used as traditional medicines. Phytochemical investigation of plants emphasizes in traditional medicines has yielded various bioactive compounds with different...
Natural product medicines: A literature update
Natural products represent major approach for the discovery and development of new drugs. An updated review on the natural products is lacking in the literature. So, in the present review, an attempt has made to pool t...