Analgesic activity of Terminalia bellerica fruit pulp aqueous extract by using acetic acid induced writhing test in Swiss albino mice by peripheral mechanism
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 2
Abstract
Objective To evaluate analgesic activity of Terminalia bellerica fruit pulp aqueous extract by acetic acid induced writhing reflex test in Swiss albino mice by peripheral mechanism Materials and MethodsAlbino mice of Swiss strain Male Femaleequal number were selected for the study and each mouse weighed about 1530gms Five experimental groups made assigned as Control Standard and three groups of test drugs at different doses and the doses were Gum acacia 1 10mlkg Diclofenac sodium 30mgkg Terminalia bellerica 9 18 and 36 mgkg respectively All the drugs were administered orally one hour before commencing the experiment followed by injecting 01 ml of 06 acetic acid intraperitoneally and writhing reflex was observed for next five minutes Observations recorded as mean SD Results obtained were analyzed by using ANOVA oneway statistical test followed by Dunnets multiple comparison test and if p value Results Our study reveals that aqueous extract of Terminalia bellerica fruit pulp in the dose of 9mgkg 483147pConclusionAqueous extract of Terminalia bellerica fruit pulp exhibited peripheral action in all the dose of 9 18 and 36 mgkg by acetic acid induced writhing reflex test in Swiss albino miceKeywords Aqueous extract Fruit pulp Peripheral analgesic activity Terminalia bellerica Writhing test
Authors and Affiliations
Barath Kumar D. , Chandrashekar R. , Manohar V. R. , Mohan Das Rai
Keywords
Related Articles
- EP ID EP478542
- DOI 10.18231/2393-9087.2018.0013
- Views 95
- Downloads 0
Study of serum glucose and cholesterol level in schizophrenic patient’s before and after treatment of olanzapine, risperidone and haloperidol
Objectives To evaluate the potential association between antipsychotics Olanzapine Risperidone and Haloperidol serum glucose level and serum cholesterol level in schizophrenic patientsIntroduction Schizophrenia is quite...
Cost analysis study of commonly used oral hypoglycaemic agents available in India- a pharmacoeconomic study
Objectives: To assess the difference in cost percentage variation of various brands of oral hypoglycaemic drugs available in single and in combination in Indian market. Materials and Methods: An observational study was c...
Ajuga bracteosa: A central Himalayan plant shows potent hypoglycemic effect in rats
Background: In the present study, a central Himalayan herb; Ajuga bracteosa Wall. ex Benth. (Neelkanthi, Ratapaati) was investigated for the probable hypoglycemic activity underlying in it. Material and Method: The hydro...
Impact of mass media on Knowledge attitude and practices (KAP) amongst the ANC mothers attending the ICTC at DrRPG Medical College, Tanda
Objectives To know the Impact of Mass Media on Knowledge attitude and practices KAP amongst the ANC mothers attending the ICTC at DrRPG Medical College TandaMaterials and MethodsThis was a Hospital based cross sectional...
Antihyperlipidemic Effect of Microbially Converted Eicosapentaenoic Acid from Rice Bran Oil in Rats
Objective: Eicosapentaenoic acid (EPA) from fish oil is known to have favourable effects on cardiovascular system by lowering the elevated lipid levels. With the intention of producing an alternative vegetarian source to...