Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 2
Abstract
Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-α, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p<0.05) decreased the number of writhes in mice at 30 mg/kg when compared to the control and Aspirin. In the hot plate induced pain test, 10 mg/kg of extract triggered comparable analgesic effect as morphine up to 2 hrs after drug administration. There was significant decrease (p<0.05) in xylene-induced ear oedema at 10 and 30 mg/kg doses of the extract with 80% and 30% when compared to control and dexamethasone. For Carrageenan-induced paw oedema in rats, 30 mg/kg elicited equal effect as indomethacin at 10 mg/kg respectively. The downward regulation/expression of TNF-α, resistin and adiponectin in contrast with control and the expression of beta-actin further indicates that Desplatsia dewevrei has both pro and anti-inflammatory activities. Conclusion: Desplatsia dewevrei methanol leaf extract is anti-inflammatory and elicits both peripherally and centrally analgesic effect.
Authors and Affiliations
Oghale Ovuakporie-Uvo, MacDonald Idu, Philip Obarisiagbon, Callistus Abode
Keywords
Related Articles
- EP ID EP49801
- DOI -
- Views 222
- Downloads 0
In vivo anti-inflammatory activity of Garcinia indica fruit rind (Kokum) in rats
The aqueous extract of Garcinia indica fruit rind (GIE) was studied for anti-inflammatory activity in carrageenan induced paw edema and cotton pellet induced granuloma in rats. Wistar rats were orally administered GIE...
Physicochemical, Phytochemical and toxicity studies on gum and mucilage from plant Abelmoschus esculentus
Okra is a popular health food due to its high fiber, vitamin C, and folate content. It is also a good source of calcium and potassium. In addition, the plant has been used medicinally in the treatment of several disord...
Wound healing potential of chloroform extract of leaf and fruit of Morinda pubescens – An in silico and in vitro approach
Genus Morinda grows in the wild areas and extensively distributed over southern India. In India, many species have been found available, of which Morinda pubescens (Synonym: Morinda tinctoria) predominantly grows as a...
Gastroprotective effect of ethanolic extract of Parmelia perlata in rats
Gastric ulcer disease (GUD) is one of the major gastrointestinal disorders which occur due to an imbalance between offensive (acid, pepsin and Helicobacter pylori) and defensive (mucin, prostaglandin and bicarbonate) f...
A Review on Heliotropism Plant: Helianthus annuus L.
Nowadays, plants are used as medicinal hub for the various disease treatments and as cosmeceuticals. Helianthus annuus L. is the source of various chemical constituents which are used for the treatment of many fatal or...