Wound healing potential of chloroform extract of leaf and fruit of Morinda pubescens – An in silico and in vitro approach
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 2
Abstract
Genus Morinda grows in the wild areas and extensively distributed over southern India. In India, many species have been found available, of which Morinda pubescens (Synonym: Morinda tinctoria) predominantly grows as a weed tree in vacant agricultural land. It has been cultivated in different parts of Tamilnadu state of India. It is widely used in the Indian traditional system of medicine. Based on the folklore claim Insilico and Invitro studies were performed using several methods. Docking experiment was carried on with iGemdock, docking software to initially study the energy binding values of constituents. Having studied the various experiments, Glycogen synthase kinase and several MMP’s [1] was used as a protein. Energy binding values showed up prompt results which indicate the affinity of the molecules towards the protein. Plant extract at three different concentrations was taken and MTT assay was performed. Then, with the help of the C2C12 cell line which is a muscle cell line, we evaluated the effect of our plant extract on the cells. Among the chloroform extract of leaf (100µg/ml) and fruit (100µg/ml), fruit extract was found to have the efficiency to fill the gaps between cells with newer ones and better elongation of cells compared to control (Nutrient treated).
Authors and Affiliations
Dhana sekar V, Gayathri P, Dinesh G, Mathan kumar S, Gopal T. K, Chamundeeswari D
Keywords
Related Articles
- EP ID EP49798
- DOI -
- Views 155
- Downloads 0
History of Cardiovascular Disease: An Overview
The term "cardiovascular disease" is often used interchangeably with “heart disease” because both terms refer to diseases of the heart or arteries. Whatever name is used — cardiovascular disease or heart disease – it...
Ethnobotany of medicinal plants used by the Zafimaniry clan in Madagascar
During an ethnobotanical survey conducted among the Zafimaniry clan in the Amoron'i Mania region of Madagascar, 164 medicinal plants species from 138 genera and 73 families are recorded to be used by local people to tr...
A Review of Regulatory Guidelines on Stability Studies
Stability could be an essential quality attribute; so, the stability program plays a very important role while manufacturing fresh pharmaceutical products. Particularly, this is in regard with the pharmaceutical prepar...
Screening for community-acquired strains of methicillinresistant Staphylococcus aureus susceptible to extracts of Centaurea nigrescens
The rates of infection by community-acquired multi-drug resistant Staphylococcus aureus have risen dramatically over fifteen years in the United States. Community-acquired multi-drug resistant Staphylococcus aureus is...
Pharmacognostical and Phytochemical Evaluation of Pilla Shukra Nashaka Anjana Varti: An ocular Ayurvedic Formulations
Pilla Shukra Nashaka Anjana Varti is an important Ayurvedic formulation containing Haritaki (Terminalia chebula Retz.), Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.), Katuki (Picrohriza...