Wound healing potential of chloroform extract of leaf and fruit of Morinda pubescens – An in silico and in vitro approach
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 2
Abstract
Genus Morinda grows in the wild areas and extensively distributed over southern India. In India, many species have been found available, of which Morinda pubescens (Synonym: Morinda tinctoria) predominantly grows as a weed tree in vacant agricultural land. It has been cultivated in different parts of Tamilnadu state of India. It is widely used in the Indian traditional system of medicine. Based on the folklore claim Insilico and Invitro studies were performed using several methods. Docking experiment was carried on with iGemdock, docking software to initially study the energy binding values of constituents. Having studied the various experiments, Glycogen synthase kinase and several MMP’s [1] was used as a protein. Energy binding values showed up prompt results which indicate the affinity of the molecules towards the protein. Plant extract at three different concentrations was taken and MTT assay was performed. Then, with the help of the C2C12 cell line which is a muscle cell line, we evaluated the effect of our plant extract on the cells. Among the chloroform extract of leaf (100µg/ml) and fruit (100µg/ml), fruit extract was found to have the efficiency to fill the gaps between cells with newer ones and better elongation of cells compared to control (Nutrient treated).
Authors and Affiliations
Dhana sekar V, Gayathri P, Dinesh G, Mathan kumar S, Gopal T. K, Chamundeeswari D
Keywords
Related Articles
- EP ID EP49798
- DOI -
- Views 217
- Downloads 0
Physicochemical, Phytochemical and toxicity studies on gum and mucilage from plant Abelmoschus esculentus
Okra is a popular health food due to its high fiber, vitamin C, and folate content. It is also a good source of calcium and potassium. In addition, the plant has been used medicinally in the treatment of several disord...
Phytochemical screening, antioxidant activity, total polyphenols and flavonoids content of different extracts of propolis from Tekel (Ngaoundal, Adamawa region, Cameroon)
Five extracts of propolis of Adamawa Cameroon were obtained by percolation and maceration with five different solvents: hexane, ethyl acetate, ethanol, methanol and water, in order of increasing polarity. Phytochemical...
Effects of crude methanol extract of the fruit of Cucumis metuliferus (Cucurbitaceae) on some haematological parameters in Cockerels
The ripe fruits of C. metuliferus were collected in Vom village, Jos South Local Government Area, Plateau State, Nigeria. The fruits were washed and sliced using clean knives, and then air dried in the laboratory and p...
Evaluation of anticancer property of mango peel and flesh after formalin treatment
Cancer is life threatening disease an d the second leading cause of death. Various phenolic compounds obtained from plant sources such as fruit, bark, leaf and roots acts against cancer but when such fruits are treated...
Chemopreventive efficacy of different doses of Ferula asafoetida oleo-gum-resin against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis
Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of deaths, especially in western countries. Its etiology is known to be a combination of hereditary, environmental,...