Analysis of clinical data of anti-dipeptidyl peptidase-like protein 6 encephalitis
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 3
Abstract
[Objective] We analyzed clinical characteristics of dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis and evaluated the effect of immunotherapy on anti-DPPX encephalitis. [Methods] A total of 9 patients with anti-DPPX encephalitis were retrospectively analyzed, including clinical manifestations, laboratory examinations, imaging features, treatment and prognosis. [Results] Nine patients were identified (medium age 45 years old, 5 were men). Neurologic disorders were multifocal: cognitive dysfunction (3 cases), psychosis (anxiety, irritability, auditory hallucination, abnormal behavior) (3 cases), CNS hyperexcitability (6 cases), brainstem (5 cases), cerebellar dysfunction (4 cases), sleep disorders (3 cases), dysautonomia (1 case), allodynia (1 case). In additional, there were 4 patients complicated with weight loss and/or gastrointestinal symptoms. CSF data showed that white cell counts were elevated in 2 patients and protein levels were elevated in 4 patients. EEG revealed epileptiform discharges in 3 patients and delta wave in 1 patient. Abnormalities were found in the brain MRIs of 4 patients including T2/FLAIR lesions in the hippocampus, insula. Seven patients received corticosteroids and six patients received plasma exchange. Seven patients subsequently treated with Mycophenolate Mofetil. Among 7 patients with adequate follow-up data, all patients had recovered to some degree and 3 of them completely remitted after 4 months to 2 years of follow-up. [Conclusion] The clinical symptoms of anti-DPPX encephalitis were diverse, the classic triad of clinical symptoms were weight loss and/or gastrointestinal disorders, CNS hyperexcitability and cognitive disorders. Long-term oral Mycophenolate Mofetil may be helpful in improving prognosis and reducing recurrence.
Authors and Affiliations
Genxia HE, Junchao. QIAN
Keywords
Related Articles
- EP ID EP750445
- DOI 10.3969/j.issn.1002-0152.2024.03.004
- Views 27
- Downloads 0
The effect evaluation of revision operation for cubital tunnel syndrome followed surgical treatment
[Objective] To explore the causes of postoperative revision for cubital tunnel syndrome(CTS),summarize the details of revision surgery for CTS and evaluate the efficacy,in order to reduce the revision probability of the...
Analysis of clinical data of anti-dipeptidyl peptidase-like protein 6 encephalitis
[Objective] We analyzed clinical characteristics of dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis and evaluated the effect of immunotherapy on anti-DPPX encephalitis. [Methods] A total of 9...
Research progress of transcranial alternating current stimulation in the treatment of cognitive impairment in neuropsychiatric diseases
Cognitive dysfunction is the impairment of higher brain functions. Cognitive impairment caused by neuropsychiatric diseases has caused serious impact on patients' quality of life and the outcome of the disease. The trans...
Combination of olfactory features with cognitive testing in diagnosis of mild cognitive impairment
[Objective] To explore the value of olfactory features combined with cognitive testing in the diagnosis of mild cognitive impairment (MCI). [Methods] From April 2021 to April 2022, 70 MCI patients (MCI group) and 236 nor...
An intervention study of Orff-music therapy for long-term hospitalized patients with schizophrenia
[Objective] This research aims to investigate the impact of Orff music therapy on long-term schizophrenic patients in hospitals. [Methods] The study was a randomized, single-blind controlled trial conducted from April,20...