Cerebellar symptoms and imaging features in neurodegenerative diseases
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 9
Abstract
Pathological, electrophysiological, and neuroimaging changes in the cerebellum can occur in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. The activation and neurodegeneration of neurons in specific cerebellar regions may contribute to the clinical symptoms and pathological processes of these neurodegenerative diseases. This article reviews the clinical assessment methods and neuroimaging studies related to cerebellar symptoms in neurodegenerative diseases. The findings suggest that structural and functional abnormalities of the cerebellum are associated with symptoms such as motor, cognitive, and emotional dysfunction in these diseases. Developing a multidimensional, systematic clinical and imaging evaluation approach centered on the cerebellum will help deepen our understanding of the cerebellum’s role in the pathogenesis of neurodegenerative diseases. It will also provide new directions for the early identification of symptoms, differential diagnosis, and the formulation of precise treatment plans.
Authors and Affiliations
Xinhui QIU, Tao QIU, Meichen LIU, Tianbai LI, Weidong. LE
Keywords
Related Articles
- EP ID EP750550
- DOI 10.3969/j.issn.1002-0152.2024.09.010
- Views 1
- Downloads 0
Differences in non-enzymatic antioxidant levels between later-life depression and younger depression
[Objective] This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages. [Methods] One hundred thirty five patients with depression (including 63 elderl...
Research progress on the correlation between imaging markers and cognitive dysfunction in cerebral small vessel disease
Some patients with cerebral small vessel disease (CSVD) may experience cognitive decline and may progress to dementia, which seriously impairs the quality of life of patients. Current studies on the correlation between C...
Incidence and predictors of early radial artery occlusion associated transradial approach
ObjectiveThis study was to explore factors related to early radial artery occlusion (RAO) associated transradial approach(TRA).MethodsPatients who underwent the TRA from July 2021 to Jan 2024 were included in our study....
A progress in neuroimaging research on the central mechanisms of botulinum toxin in the treatment of focal dystonia
Botulinum toxin (BoNT) is currently the first-line method for treating focal dystonia, which causes muscle paralysis by chemical denervation. Recent neuroimaging studies have found that BoNT treatment could alter neuropl...
Progress of long chain non-coding RNAs in the inflammatory response to cerebral ischemia-reperfusion injury
Inflammatory response is one of the key mechanisms of cerebral ischemia/reperfusion injury (CIRI), which seriously affects the prognosis of patients. In recent years, it has been found that long non-coding RNA (LncRNA) i...