Differences in non-enzymatic antioxidant levels between later-life depression and younger depression
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages. [Methods] One hundred thirty five patients with depression (including 63 elderly patients aged 60 years and older, and 72 young and middle-aged patients under 60 years old) and 98 healthy controls (including 46 elderly controls aged 60 years and older, and 52 young and middle-aged controls aged under 60 years old) were enrolled. Serum levels of non-enzymatic antioxidants (uric acid, total bilirubin, albumin) were assessed. [Results] Multiple analysis of variance showed the main effects of depression factors on uric acid and total bilirubin were significant (P<0.05). Uric acid [(314.30±85.18) μmol/L vs. (339.68±85.27) μmol/L], total bilirubin [(12.81±6.16) μmol/L vs. (15.09±5.97) μmol/L] levels were lower in patients with depression than in controls (P<0.05). There was an interactive effect between age and depression factors on the levels of albumin (P<0.001), and the levels of albumin [(41.05±3.97) g/L vs. (46.01±4.49) g/L] were lower in group of the elderly patients with depression than those in group of the young and middle-aged patients with depression (P<0.01). [Conclusion] Patients with depression have abnormalities in levels of non-enzymatic antioxidants which are more severe in elderly patients.
Authors and Affiliations
Ning FAN, Qi ZHANG, Luyuan BAI, Wenxuan ZHAO, Yajun YUN, Jiangling YAN, Xiaole HAN, Fude. YANG
Keywords
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- EP ID EP750488
- DOI 10.3969/j.issn.1002-0152.2024.04.005
- Views 26
- Downloads 0
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