Differences in non-enzymatic antioxidant levels between later-life depression and younger depression
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages. [Methods] One hundred thirty five patients with depression (including 63 elderly patients aged 60 years and older, and 72 young and middle-aged patients under 60 years old) and 98 healthy controls (including 46 elderly controls aged 60 years and older, and 52 young and middle-aged controls aged under 60 years old) were enrolled. Serum levels of non-enzymatic antioxidants (uric acid, total bilirubin, albumin) were assessed. [Results] Multiple analysis of variance showed the main effects of depression factors on uric acid and total bilirubin were significant (P<0.05). Uric acid [(314.30±85.18) μmol/L vs. (339.68±85.27) μmol/L], total bilirubin [(12.81±6.16) μmol/L vs. (15.09±5.97) μmol/L] levels were lower in patients with depression than in controls (P<0.05). There was an interactive effect between age and depression factors on the levels of albumin (P<0.001), and the levels of albumin [(41.05±3.97) g/L vs. (46.01±4.49) g/L] were lower in group of the elderly patients with depression than those in group of the young and middle-aged patients with depression (P<0.01). [Conclusion] Patients with depression have abnormalities in levels of non-enzymatic antioxidants which are more severe in elderly patients.
Authors and Affiliations
Ning FAN, Qi ZHANG, Luyuan BAI, Wenxuan ZHAO, Yajun YUN, Jiangling YAN, Xiaole HAN, Fude. YANG
Keywords
Related Articles
- EP ID EP750488
- DOI 10.3969/j.issn.1002-0152.2024.04.005
- Views 61
- Downloads 0
Advance in research on EEG technology in non-suicidal self-injurious behaviour and suicidal ideation in depression
Non-suicidal self-injury behavior and suicidal ideation are important risk factors for suicide attempts in patients with depression. At present, studies have found that there are obvious differences in electroencephalogr...
The correlation between cognitive impairment and DNA methylation in the GRIN2B gene promoter region in bipolar depression patients with anxiety symptom
[Objective] To explore the correlation between cognitive function and methylation levels of various CpG sites in the promoter region of the glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B) gene in patients wit...
Advances in tissue kallikrein for acute ischemic stroke
Acute ischemic stroke (AIS) is a common neurological disorder that still presents many challenges despite advancements in diagnostic and therapeutic techniques. Tissue kallikrein (TK), a cardiovascular and cerebrovascula...
A case-control study on the attention characteristics of patients with stable schizophrenia
[Objective] To investigate the attention characteristics of patients with stable schizophrenia. [Methods] Fifty-five stable schizophrenic patients and 55 healthy subjects were included in the study. The attention network...
Paroxysmal motor induced dyskinesia caused by PRRT2 gene c.776del mutation
This article reported a typical case of paroxysmal kinesigenic dyskinesia (PKD). The patient was a 26-year-old female with a medical history of 10 years. The patient manifested as paroxysmal choreoathetosis of the limb a...