The correlation between cognitive impairment and DNA methylation in the GRIN2B gene promoter region in bipolar depression patients with anxiety symptom
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 5
Abstract
[Objective] To explore the correlation between cognitive function and methylation levels of various CpG sites in the promoter region of the glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B) gene in patients with bipolar depression accompanied by anxiety symptoms. [Methods] According to the 14-item Hamilton anxiety rating scale (HAMA) score, 31 bipolar depression patients were divided into a group of 15 with anxiety symptoms and a group of 16 without anxiety symptoms. Sixteen healthy individuals were selected as controls during the same period. The Montreal cognitive assessment (MoCA), digital span test (DST), trail making test A (TMT-A), and Stroop color and word test (SCWT) were used to measure cognitive areas such as global cognitive function，attention and executive control，information processing speed，executive function in three groups. The DNA methylation levels of the CpG site in the GRIN2B gene promoter region in the peripheral blood of all participants were measured using Massarray spectrometry. [Results] The CpG sites showing differences in DNA methylation levels among the three groups were CpG3, CpG5, CpG7, CpG10, and CpG12 (P<0.05), and the level of CpG12 methylation was lower in the group with anxiety than in the group without anxiety (36.23%±16.41% vs. 50.20%±19.79%, P<0.05). Partial correlation analysis showed that, in the group with anxiety, poor naming ability was correlated with the lower methylation level of GRIN2B gene's CpG4 (r=0.670, P=0.034), poor executive function was correlated with the lower CpG6 methylation level (r=0.926, P<0.001), poor attention was correlated with the higher CpG8 methylation level (r=-0.810, P=0.025), poor verbal memory was correlated with the higher CpG9 methylation level (r=-0.810, P<0.001), and poor abstract ability was correlated with the higher CpG10 methylation level (r=-0.756, P=0.011). [Conclusion] The DNA methylation level in the promoter region of the GRIN2B gene may be associated with cognitive impairment and anxiety symptoms in patients with bipolar depression.
Authors and Affiliations
Hao YU, Chengji WANG, Yao WU, Shaohong. Xinjiang Medical University ZOU
Keywords
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- EP ID EP750506
- DOI 10.3969/j.issn.1002-0152.2024.05.004
- Views 25
- Downloads 0
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