ANALYSIS OF EFFECT OF LIPID PROFILE ON CONTROLLED/UNCONTROLLED DIABETES MELLITUS AND EVALUATING LINK BETWEEN DIABETES, DYSLIPIDAEMIA AND CORONARY ARTERY DISEASE.
Journal Title: International Journal of Basic and Applied Physiology - Year 2018, Vol 7, Issue 1
Abstract
With triad of diabetes, dyslipidaemia and coronary artery disease on rise WHO and IDF coined term called metabolic syndrome encompassing all three components. Hence it’s imperative to study effects of lipid profile abnormalities not only on diabetes mellitus but also with coronary artery diseases. Methods: In total, 50 cases of Type 1 DM, 50 cases of Type 2 DM, 50 cases of control were included in present study which was conducted at Guru Gobindsinh Hospital, Jamnagar by Physiology department, M. P. Shah medical college, Jamnagar, Gujarat, India. History taking and clinical examination were conducted to identify associated coronary diseases. Apart from FBS and urine sugar, lipid profile (i.e. S. Cholesterol, S. Triglyceride, S. HDL, S. VLDL, S. LDL) was done using enzymatic colorimetric tests. Prior consent was taken from patients. Results: In type 1 DM, uncontrolled diabetes patients had higher level of S. Cholesterol, S. Triglyceride, S. VLDL and S. LDL and low level of HDL compared to controlled diabetes patients. Similar results were obtained in Type 2 DM as well. In Type 1 DM, 5 out 50 cases were having coronary diseases associated with DM while in Type 2 DM nearly 18 cases out of 50 were having associated coronary condition indicating that CAD is more associated with Type 2 than Type 1 DM. Interpretation & conclusion: Incidence of CAD in male and female patients in present study was 22 & 11 respectively and nearly 33% population had CAD with DM. Similar observations were found in Mrunalini et al8 study with 33% and Lento S. et al6 study with 39.09%. High mortality in DM is mainly associated with cardiovascular complications which are in turn because of high blood sugar, dyslipidaemia and other associated blood coagulation and vascular factor deficiencies or abnormalities.
Authors and Affiliations
Nileshwari vala, Dr. Gitesh Dubal
Keywords
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