Analysis of Height Indexes of Girls with Turner Syndrome Depending on Karyotype in Ukrainian Population
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 5, Issue 69
Abstract
Objective: to determine the parameters of stature and bone age in girls with Turner syndrome (TS) in Ukrainian population depending on the age and karyotype, the final height compared with healthy girls, as well as the state of somatotropic pituitary function in girls with TS. Materials and methods. A retrospective analysis of 502 registration cards of girls with TS aged 11 months to 17 years inclusively has been carried out for a period from 2004 to 2014. In-depth examination was conducted in children who underwent outpatient or inpatient treatment in National children’s specialized hospital «Mother and child healthcare» and Ukrainian scientific and practical centre for endocrine surgery, transplantation of endocrine organs and tissues. We have determined physical development of a child, bone age, presence of growth failure, level of insulin-like growth factor 1 (IGF-1). To compare growth performance of children with TS and healthy girls in the general population, we used the results of a survey of the physical development of 525 somatically healthy girls with normal female karyotype aged 10 months to 17 years inclusively (the control group). Results. The difference in height in girls with TS and somatically healthy girls with normal female karyotype was significant (p < 0.05) in all the age groups older than one year, increased with age, the maximum was in adolescence. The degree of growth retardation in girls with TS averages –3.1 ± 1.1 SD with maximum delay in 14 years. Bone age in girls with TS is delayed in all age groups, with a maximum difference with real age in 17 years. No significant difference in indicators of growth, bone age, level of stimulated growth hormone and IGF-1in girls with the TS with different karyotype (p > 0.05) is observed, which indicates that the karyotype formula does not affect these figures. Most of the girls with TS have a normal somatotropic function, but 35.7 % have a partial or complete deficiency of growth hormone.
Authors and Affiliations
N. B. Zelinska, I. Yu. Shevchenko, N. L. Pohadaieva, Ye. V. Hloba
Keywords
Related Articles
- EP ID EP219685
- DOI -
- Views 100
- Downloads 0
Girls Precocious Sexual Development: Capability of Laboratory Diagnosis
The importance of timely detection of the causes of precocious sexual development is associated, firstly, with the possible existence of tumor, as well as with the states accompanied by the accelerated puberty. Key role...
Features of the Course and Control of Bronchial Asthma among Schoolchildren with Overweight
The study of clinical features and identification of inflammatory markers in the bronchi of 52 schoolchildren with overweight and bronchial asthma has been carried out. It was found that overweight children are character...
Dynamics of Levels of Renin-Angiotensin System Hormones in Patient with Simple Unilocular Renal Cysts Complicated with Secondary Hypertension
In this article there are presented the results of surgical correction of secondary hypertension in 95 patients suffering from simple solitary cysts of renal parenchyma. In thesе patients there was carried out the study...
Do we need a diagnosis of metabolic syndrome?
The article presents different approaches to defining the metabolic syndrome from viewpoint of the experts of the National Cholesterol Education Program (USA), the World Health Organization and verifying this diagnosis a...
Experience of Modern Premixed Insulin Use in Treatment of Diabetes Mellitus
No abstract