Diabetes mellitus and atherosclerosis. The role of inflammatory processes in pathogenesis (literature review)
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 7
Abstract
The review of the literature summarizes and analyzes the material on inflammatory processes accompanying cardiovascular complications in diabetes mellitus. The role of endothelial dysfunction is shown leading to an increase in the permeability of the endothelium, accumulation of lipoproteins in the vessel wall, their modification, formation and secretion of cell adhesion molecules, which in turn leads to involvement of monocytes and their differentiation into inflammatory macrophages. The role of scavenger receptors in the deposition of cholesterol and the formation of foam cells was noted. The mechanisms of the inflammatory process initiation and the formation of inflammasоmes are considered in detail. The scheme of transduction of proinflammatory signals in the cell and participation of the key factor NF-κB integrating all incoming information and controlling the transactivation of genes involved in inflammation are described. It is shown that inflammation is key process in the development of vascular diseases in diabetes mellitus, and the suppression of these processes inhibits the progression of the disease reducing arterial damage and contributing to their healing.
Authors and Affiliations
L. K. Sokolova, V. M. Pushkarev, V. V. Pushkarev, O. I. Kovzun, M. D. Tronko
Impact of Nonselective Laryngeal Reinnervation on Main Voice Characteristics
The possibility and long-term results of non-selective surgical reinnervation by primary and delayed anastomosis of recurrent laryngeal nerve (RLN) with the one of the peripheral neck nerve (proximal RLN part, main part...
Influence of Endocrine Diseases on Reproductive System Functioning
In the lecture the questions of endocrine diseases influence on the reproductive system functioning are being considered. The reproductive system of woman is analyzed as a complex of interdependent structural elements: h...
News of endocrinology
.
Clinical and Morphological Description of Cardiovascular System and Medical and Social Rehabilitation of Diabetic Patients
The study described in the paper was aimed to investigate cardiovascular system functioning in diabetic patients. The impairments of systolic and diastolic myocardial functions combined with different types of left ventr...
Aldosterone synthase gene polymorphism in alimentary obesity, metabolic syndrome components, some secondary forms of arterial hypertension, pathology of the adrenals glands core (literature review)
Hormonal factors of adrenal origin belong to the pathophysiological mechanisms of the formation and progression of arterial hypertension (AH) and should be considered while developing differentiated approaches to the tr...