Analysis of mdr1-1Δ mutation of MDR1 gene in the “Cimarron Uruguayo” dog

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Analysis of mdr1-1Δ mutation of MDR1 gene in the “Cimarron Uruguayo” dog

Journal Title: Revista MVZ Cordoba - Year 2013, Vol 18, Issue 2

Abstract

Objective. The aim of this paper is to analyze the frequency of the mdr1-1D mutation of the MDR1 gene in a dog sample of the Uruguayan Cimarron breed with the objective of increasing the knowledge of this breed’s genome. Materials and methods. Thirty-six animals of this breed were analyzed. The MDR1 gene region, which includes the location where the mutation would be present, was amplified by PCR. Results. The mutation was not detected in any of the analyzed Uruguayan Cimarron. Conclusions. The lack of described ivermectin intoxication cases in veterinary clinic in this breed is explained by the lack of the mutation object of this study. The sequence studied in Cimarron dogs is kept compared to other breeds, except Collies and related breeds (Border Collie, Bearded Collie, Old English sheepdog).

Authors and Affiliations

Rosa Gagliardi B, M. Sc *| Universidad de la República, Facultad de Veterinaria, Área Genética. Montevideo, C.P. 11600, Uruguay.Correspondencia: rgagliar@gmail.com., Cristina García G, Ph. D| Universidad de Zaragoza, Facultad de Veterinaria, Laboratorio de Citogenética y Genética Molecular. Zaragoza, C. P. 50013, España., Silvia Llambí D, Ph. D| Universidad de Zaragoza, Facultad de Veterinaria, Laboratorio de Citogenética y Genética Molecular. Zaragoza, C. P. 50013, España., María Arruga L, Ph. D| Universidad de Zaragoza, Facultad de Veterinaria, Laboratorio de Citogenética y Genética Molecular. Zaragoza, C. P. 50013, España.

Keywords

Dogs mutations pharmacogenetics

EP ID EP3309
DOI -
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