Analysis of Patterns of Recurrence & Survival In Triple Negative Breast Cancer Patients In A Rural Based Medical College Hospital of West Bengal, India : A Retrospective Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Introduction:Breast cancer is a heterogeneous disease with different morphological features and clinical behavior [1]. One of its subtypes is Triple Negative Breast Cancer (TNBC) which means no expression of Estrogen & Progesterone receptor and Her 2- neu status.[2,3] Aim of this study is to evaluate recurrence pattern & survival in patients diagnosed with TNBC from April 2010 to March 2015 in a rural medical college of West Bengal. Total no of patients included in this study (n) was 239. Disease free survival ( DFS) and overall survival (OS) were calculated using the Kaplan – Meier method. Results - Median age at the time of diagnosis was 40 yrs( range 22-72 yr) . Majority of patients were in stage II and stage III disease. After 3 yrs total 84 patients (35.14%) developed recurrence of which most common was visceral metastases ( 68.36%) . DFS at 3 yrs was 64.43%) and OS was 75.73%). After 5 yrs metastases occurred in 41.42% .The highest risk of recurrence was during first 3 yrs after primary treatment. 5 yr DFS 61.08% and Os 71.54%. Conclusion:TNBC is an aggressive disease involving younger & pre menopausal patients with higher stage. TNBC has a unique pattern of metastasis usually occur in first 3 years of diagnosis & it is mostly visceral. More no. of prospective randomized controlled trials are required to find out more effective treatment to increase survival ( DFS & OS) in TNBC patients
Authors and Affiliations
Dr. Ramkrishna Mandal, Dr. Santanu Acharyya, Dr. Md Arshad Mollah,, Dr. Arunava Ghosh, DrAbhay Charan Pal
Keywords
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- EP ID EP250468
- DOI 10.9790/0853.1612023641
- Views 54
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