Analysis of phytochemical profile and genotoxicity of crude methanolic extracts of Quassia indica (Gaertn.) with antiinflammatory and antioxidant properties.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 2
Abstract
:The use of traditional medicine is expanding to newer horizons and plants still remain as the novel source of structurally important compounds that lead to the development of innovative drugs. It is believed that about 80% of world‟s population use plants as their primary source of medicinal agents. In this juncture, the present study was undertaken to analyze the antioxidant, anti-inflammatory potentiality and genotoxicity of the medicinal herb Quassia indica. An attempt has also been made in the present study for supplementing evidence from in-vitro studies with information on phytochemical profiling, and genotoxic nature to establish the safe range of extract consumption. The results reveal potential anti inflammatory and anti oxidant activity when compared to the respective standards. In general, more activity was obtained when using more concentrated decoctions of the plant extract studied. The systematically performed in vitro assays revealed that the tested plant extract may find in therapy as agent with high pharmaceutical value. Treatment of extract of Quassia indica inhibited root growth and developed genotoxic effect in onion meristem cells. The bridges, breaks, lagging and multipolar anaphase chromosomes were observed at all concentrations studied. Various types of chromosomal abnormalities such as chromosomal lagging, disruptive anaphase, irregularity in the movement and arrangement of chromosome, chromosome stickiness, vagrant chromosomes, polar deviation and abnormal dispersed metaphase were recorded. As the human clinical evidence is still limited, future research needs to define the actual magnitude of health benefits, establishing the safe range of extract consumption with these benefits and elucidating the mechanism of action. In addition, the plant is a good candidate for further phytochemical and chromatographic studies to isolate and fully characterize the compound related to this in vitro biological activity.
Authors and Affiliations
*Chithra Vijayan, P Preeja2, K Murugan3
Keywords
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